Evidence map›Paper›PMID 31529023›Full record

ArticleBrain : a journal of neurology2019

Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts.

Shen Li, Byoung Chol Oh, Chengyan Chu, Antje Arnold, Anna Jablonska, Georg J Furtmüller, Hua-Min Qin, Johannes Boltze, Tim Magnus, Peter Ludewig and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain : a journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. ACS applied materials & interfaces · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Shen LiNeurology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, Dalian, China.
Byoung Chol OhDepartment of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chengyan ChuDivision of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Antje ArnoldDivision of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anna JablonskaDivision of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Georg J FurtmüllerDepartment of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hua-Min QinDivision of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johannes BoltzeSchool of Life Sciences, University of Warwick, Coventry, UK.
Tim MagnusNeurology Department, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Peter LudewigNeurology Department, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mirosław JanowskiDivision of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerald BrandacherDepartment of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Piotr WalczakDivision of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USDalian Medical University · CNUniversität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Warwick · GB

Funding

Treatment of ALS based on transplantation of glial restricted progenitorsR01NS091110 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WALCZAK, PIOTR · 2015 to 2019
$1.8M
Image-Guided Stem Cell Therapy of Perinatal Asphyxia in a Large Animal ModelR01NS091100 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JANOWSKI, MIROSLAW · 2015 to 2019
$1.8M
Two-pronged therapeutic approach for glioblastoma: high dose radiation therapy then repair of radiation-induced brain injuryR01NS102675 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WALCZAK, PIOTR · 2018 to 2019
$511k
NINDS NIH HHS R01 NS091100NINDS NIH HHS R01 NS091110NINDS NIH HHS R01 NS102675
6 · The paper itself

Abstract

The immunological barrier currently precludes the clinical utilization of allogeneic stem cells. Although glial-restricted progenitors have become attractive candidates to treat a wide variety of neurological diseases, their survival in immunocompetent recipients is limited. In this study, we adopted a short-term, systemically applicable co-stimulation blockade-based strategy using CTLA4-Ig and anti-CD154 antibodies to modulate T-cell activation in the context of allogeneic glial-restricted progenitor transplantation. We found that co-stimulation blockade successfully prevented rejection of allogeneic glial-restricted progenitors from immunocompetent mouse brains. The long-term engrafted glial-restricted progenitors myelinated dysmyelinated adult mouse brains within one month. Furthermore, we identified a set of plasma miRNAs whose levels specifically correlated to the dynamic changes of immunoreactivity and as such could serve as biomarkers for graft rejection or tolerance. We put forward a successful strategy to induce alloantigen-specific hyporesponsiveness towards stem cells in the CNS, which will foster effective therapeutic application of allogeneic stem cells.

Indexed as

Immune ToleranceMyelin SheathAdoptive TransferAllograftsAnimalsCytokinesGraft RejectionLymphocyte Culture Test, MixedMaleMiceMice, Inbred C57BLMicrogliaMicroRNAsNeural Stem CellsStem Cell TransplantationT-LymphocytesCytokinesMicroRNAsco-stimulation blockadeglial-restricted progenitorsimmunological tolerancemyelinationtransplantation

Identifiers

PMID31529023
PMCPMC13370129
OpenAlexW2974397086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.