Observational studyRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia2019
Determination of a cutoff value for medication regimen complexity index to predict polypharmacy in HIV+ older patient.
Observational study in Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ageing with HIV: Medicine Optimisation Challenges and Support Needs for Older People Living with HIV: A Systematic Review.Drugs & aging · 2023Pooled it
- What is polypharmacy in people living with HIV/AIDS? A systematic review.AIDS research and therapy · 2022Pooled it
- Impact of a CMO-Based Pharmaceutical Care Model on 3-HIT Criteria in Older People Living with HIV: The DIS3HIT Project.Patient preference and adherence · 2026Article
- Comparison of perceived versus actual care complexity in HIV-positive patients receiving antiretroviral treatment: The STRATPATIENT study.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Observational
- Influence of antiretroviral therapy on frailty among people living with HIV.Scientific reports · 2025Observational
- Factors Associated with Adequate Quality of Life Levels in HIV Patients During a Five-Year Longitudinal Study.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Observational
- Association of medication regimen complexity index with ADRs in HIV/AIDS patients: a retrospective cohort study.Frontiers in pharmacology · 2025Article
- A Prospective Study of the Medication Regimen Complexity Index and Hospitalization Due to Adverse Drug Reactions Among People Living with HIV.Medicina (Kaunas, Lithuania) · 2024Article
- Missed opportunity: low awareness of undetectable equals untransmittable (U = U) among adolescents living with HIV.AIDS research and therapy · 2024Article
- Prevalence of compliance with PIMDINAC criteria among elderly people living with HIV and in non-infected outpatients with other chronic diseases.European journal of hospital pharmacy : science and practice · 2024Article
- Polypharmacy and medication regimen complexity in transfusion-dependent thalassaemia patients: a cross- sectional study.International journal of clinical pharmacy · 2024Observational
- Use of different anticholinergic scales and their correlation with anticholinergic symptom burden in a cohort of people living with HIV.The Journal of antimicrobial chemotherapy · 2024Article
- Polypharmacy and health related quality of life among older adults on antiretroviral therapy in a tertiary hospital in Tanzania: a hospital-based cross-sectional study.BMC infectious diseases · 2023Article
- Potentially inappropriate medications according to Marc, STOPP and PRISCUS criteria in a cohort of elderly HIV+ patients. The COMMPI project.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Article
- Medication Regimen Complexity and Medication Burden Among Patients With Type 2 Diabetes Mellitus: A Retrospective Analysis.Frontiers in pharmacology · 2022Article
- Prevalence and global trends of polypharmacy among people living with HIV: a systematic review and meta-analysis.Therapeutic advances in drug safety · 2022Article
- High level of medication regimen complexity index correlate with worse quality of life in people living with HIV.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Observational
- Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots.Pharmacotherapy · 2021Article
- Prevalence of prescription of the Top-10 drug classes to avoid in elderly people living with HIV in a real practice cohort.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Observational
- Beliefs and attitudes about deprescription in older HIV-infected patients: ICARD Project.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHIV+ patients have increased their life expectancy with a parallel increase in age-associated co-morbidities and pharmacotherapeutic complexity. The aim of this study was to determine an optimal cutoff value for Medication regimen complexity index (MRCI) to predict polypharmacy in HIV+ older patients.
methodsA transversal observational single cohort study was conducted at a tertiary Hospital in Spain, between January 1st up to December 31st, 2014. Patients included were HIV patients over 50 years of age on active antiretroviral treatment. Prevalence of polypharmacy and it pattern were analyzed. The pharmacotherapy complexity value was calculated through the MRCI. Receiver operating characteristic curve analyses were used to calculate the area under the curve (AUC) for the MRCI value medications to determine the best cutoff value for identifying outcomes including polypharmacy. Sensitivity and specificity were also calculated.
resultsA total of 223 patients were included. A 56.1% of patients had polypharmacy, being extreme polypharmacy in 9.4% of cases. Regarding the pattern of polypharmacy, 78.0% had a cardio-metabolic pattern, 12.0% depressive-psychogeriatric, 8.0% mixed and 2.0% mechanical-thyroidal. The ROC curve demonstrated that a value of medication complexity index of 11.25 point was the best cutoff for predict polypharmacy (AUC=0.931; sensitivity= 77.6%; specificity=91.8%).
conclusionsA cut-off value of 11.25 for MRCI is proposed to determine if a patient reaches the criterion of polypharmacy. In conclusion, the concept of polypharmacy should include not only the number of prescribed drugs but also the complexity of them.
Indexed as
Identifiers
31528986PMC6790892What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.