ArticleJournal of current ophthalmology2019
Assessment of the changes in corneal biomechanical properties after collagen cross-linking in patients with keratoconus.
Article in Journal of current ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Corneal biomechanical property changes following corneal collagen cross-linking in keratoconus: a systematic review and meta-regression analysis.International ophthalmology · 2025Pooled it
- Biomechanical changes in keratoconus after customized stromal augmentation.Taiwan journal of ophthalmologyTrial
- Corneal biomechanical and tomographic outcomes following accelerated cross-linking in keratoconus: a focus on cone localization.Japanese journal of ophthalmology · 2026Article
- Evaluation of refractive, tomographic and biomechanical changes after customized accelerated corneal collagen cross-linking in keratoconus patients: a retrospective observational study.BMC ophthalmology · 2025Observational
- Assessing UVA and Laser-Induced Crosslinking via Brillouin Microscopy.Journal of biophotonics · 2025Article
- A novel corneal indentation device for comparison of corneal tangent modulus before and after FS-LASIK in vivo.Biomedical engineering online · 2025Article
- Femtosecond Laser- Assisted Customized CAIRS In Keratoconus Patients After ICRS Explantation: A Prospective Case Series: Customized CAIRS in post ICRS extrusion keratoconus patients.Journal of cataract and refractive surgery · 2024Article
- Determination of efficacy of repeated CXL and probable risk factors in patients with progressive keratoconus.International ophthalmology · 2023Article
- Review
- Evaluation of the Relationship Between the Changes in the Corneal Biomechanical Properties and Changes in the Anterior Segment OCT Parameters Following Customized Corneal Cross-Linking.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021Review
- Corneal Biomechanical Assessment with Ultra-High-Speed Scheimpflug Imaging During Non-Contact Tonometry: A Prospective Review.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Advances in Biomechanical Parameters for Screening of Refractive Surgery Candidates: A Review of the Literature, Part III.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Review
- Corneal Biomechanical Parameters after 60-Year-Old.Journal of current ophthalmologyArticle
- Corneal Biomechanical Changes after Corneal Cross-Linking in Patients with Keratoconus.Journal of current ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the changes in biomechanical properties of the cornea after treatment of keratoconus patients with UV-A/riboflavin corneal collagen cross-linking (CXL) using Corvis ST (Oculus, Wetzlar, Germany) and Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments, Inc., Buffalo, NY, USA) devices.
methodsIn this prospective, observational case series, 48 eyes from 48 consecutive patients with progressive keratoconus were enrolled. Patients with history or signs of ocular disorders other than keratoconus, previous eye surgery, systemic diseases, or inability to cooperate with any measurement device were excluded. Corvis ST and ORA images were obtained at baseline and 4 months after CXL. The primary outcome measures comprised Corvis ST corneal biomechanical factors [time of highest concavity (T), time of applanation 1 (T1), time of applanation 2 (T2), length of applanation 1 (L1), length of applanation 2 (L2), velocity of applanation 1 (V1), velocity of applanation 2 (V2), deformation amplitude (DA), peak distance (PD), and radius (R)] and the ORA parameters [corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-related IOP (IOPg), cornea-compensated IOP (IOPcc), and waveform score (WS)].
resultsThe mean [± standard deviation (SD)] age of patients was 20 ± 5 years, and 27 (56%) were male. At baseline, the averages of the refraction, mean keratometry, and keratometric astigmatism were -3.0 ± 1.8 diopter (D), 47.0 ± 1.8 D, and 3.5 ± 1.5 D, respectively. According to Corvis ST, L2 increased from 0.83 ± 0.25 mm at baseline to 1.15 ± 0.57 mm after CXL; and V2 decreased from -0.81 ± 0.08 to -0.94 ± 0.26 m/s (
conclusionsAccording to in vivo observation with Corvis ST and ORA, CXL induces significant changes in corneal biomechanical properties in cases with keratoconus. The parameters with significant changes (L2 and V2) may reflect increased stiffness of the treated cornea. The importance of such observations should be elucidated in future studies.
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