Evidence map›Paper›PMID 31528718›Full record

ArticleInnovation in aging2019

How Does Subjective Age Get "Under the Skin"? The Association Between Biomarkers and Feeling Older or Younger Than One's Age: The Health and Retirement Study.

Bharat Thyagarajan, Nathan Shippee, Helen Parsons, Sithara Vivek, Eileen Crimmins, Jessica Faul, Tetyana Shippee

Abstract read
In one paragraph

Article in Innovation in aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Review
  4. Daily Stressor Appraisals and Subjective Age Predict Daily Affective Ratings.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  5. Mexican Health and Aging Study Biomarker and Genetic Data Profile.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
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  10. Review
  11. Article
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  13. Article
  14. Subjective Aging and Incident Cardiovascular Disease.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.ORCID 0000-0001-6968-6985
Nathan ShippeeDivision of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis.
Helen ParsonsDivision of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis.
Sithara VivekDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.
Eileen CrimminsDavis School of Gerontology, University of Southern California-Davis, Los Angeles.
Jessica FaulInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor.ORCID 0000-0002-6969-6478
Tetyana ShippeeDivision of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, HIRAM BELTRAN-SANCHEZ · 1999 to 2026
$17.9M
Biological Underpinnings of Socioeconomic Differentials in Health and MortalityR01AG060110 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M · 2018 to 2022
$2.6M
NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG060110NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThough subjective age is a well-recognized risk factor for several chronic diseases, the biological basis for these associations remains poorly understood. RESEARCH DESIGN AND

methodsWe used new comprehensive biomarker data from the 2016 wave of the nationally representative Health and Retirement Study (HRS) to evaluate the association between biomarker levels and self-reported subjective age in a subset of 3,740 HRS participants who provided a blood sample. We measured biomarkers in seven biological domains associated with aging: inflammation, glycemia, lipids, liver function, endocrine function, renal function, and cardiac function. The primary outcome was the age discrepancy score (subjective age - chronological age) categorized as those who felt younger, older, or the same as their chronological age (reference group). Analyses adjusted for comprehensive psychosocial factors (chronic stress index, depression score), demographic factors (race, sex, body mass index, marital status, physical activity), and prevalence of chronic health conditions (comorbidity index).

resultsThe prevalence of clinically relevant reduced levels of albumin concentrations was lower in those who felt younger (8.8% vs. 16.0%; DISCUSSION AND IMPLICATIONS: These results suggest that people who feel younger may have favorable biomarker profiles and as a result may have lower prevalence of age-related diseases when compared with those who feel older or those who feel the same as their chronological age.

Indexed as

Age discrepancy scoreBiological domainsPhysiological aging

Identifiers

PMID31528718
PMCPMC6736363

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.