Evidence map›Paper›PMID 31528631›Full record

ReviewMicrobial cell (Graz, Austria)2019

Diverse conditions support near-zero growth in yeast: Implications for the study of cell lifespan.

Jordan Gulli, Emily Cook, Eugene Kroll, Adam Rosebrock, Amy Caudy, Frank Rosenzweig

Open access · goldAbstract readReview
In one paragraph

Review in Microbial cell (Graz, Austria), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jordan GulliSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Emily CookSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Eugene KrollSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Adam RosebrockDonnelly Centre for Cellular and Biological Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Amy CaudyDonnelly Centre for Cellular and Biological Research and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Frank RosenzweigSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Georgia Institute of Technology · US

Funding

Evolution of drug resistance in Candida glabrataR01AI136992 · NIAID · STANFORD UNIVERSITY · PI SHERLOCK, GAVIN J · 2019 to 2022
$2.7M
NIAID NIH HHS R01 AI136992
6 · The paper itself

Abstract

Baker's yeast has a finite lifespan and ages in two ways: a mother cell can only divide so many times (its replicative lifespan), and a non-dividing cell can only live so long (its chronological lifespan). Wild and laboratory yeast strains exhibit natural variation for each type of lifespan, and the genetic basis for this variation has been generalized to other eukaryotes, including metazoans. To date, yeast chronological lifespan has chiefly been studied in relation to the rate and mode of functional decline among non-dividing cells in nutrient-depleted batch culture. However, this culture method does not accurately capture two major classes of long-lived metazoan cells: cells that are terminally differentiated and metabolically active for periods that approximate animal lifespan (e.g. cardiac myocytes), and cells that are pluripotent and metabolically quiescent (e.g. stem cells). Here, we consider alternative ways of cultivating

Indexed as

baker's yeastchronological lifespan (CLS)encapsulationgiant yeast coloniesimmobilized cell reactorsnear-zero growthretentostatsstarvation

Identifiers

PMID31528631
PMCPMC6717879
OpenAlexW2970869574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.