ArticleSurgical neurology international2019
Skull base chordoma treated with proton therapy: A systematic review.
Article in Surgical neurology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Proton beam and carbon ion radiotherapy in skull base chordoma: a systematic review, meta-analysis and meta-regression with trial sequential analysis.Neurosurgical review · 2024Pooled it
- Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis.Radiation oncology (London, England) · 2022Pooled it
- Protons versus photons for the treatment of chordoma.The Cochrane database of systematic reviews · 2021Pooled it
- A refined treatment strategy for skull base chordoma: A protocol and management algorithm.Neurosurgical review · 2025Review
- Skull base chordomas - emphasis on surgical strategy and recurrence-free survival.Medicine and pharmacy reports · 2025Article
- Article
- Outcomes of the Endoscopic Endonasal Approach for the Treatment of Clival Chordomas: A Single-Center Experience.Journal of neurological surgery. Part B, Skull base · 2024Article
- Proton beam therapy for clival chordoma: Optimising rare cancer treatments in Australia.Journal of medical radiation sciences · 2024Review
- Radiotherapy in bone sarcoma: the quest for better treatment option.BMC cancer · 2023Review
- Activity of pemetrexed in pre-clinical chordoma models and humans.Scientific reports · 2023Article
- Craniovertebral Junction Instability after Oncological Resection: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Systematic Review Comparing Open versus Endoscopic Surgery in Clival Chordomas and a 10-Year Single-Center Experience.Journal of neurological surgery. Part B, Skull base · 2022Article
- Opportunities and advances in the use of Proton Radiotherapy for Management of Central Nervous System and Base of Skull Tumors.Advances in oncology · 2022Article
- Ectopic Recurrence of Skull Base Chordoma after Proton Therapy.Current oncology (Toronto, Ont.) · 2022Article
- Circulating tumor DNA - A potential aid in the management of chordomas.Frontiers in oncology · 2022Review
- An Integrated Management Paradigm for Skull Base Chordoma Based on Clinical and Molecular Characteristics.Journal of neurological surgery. Part B, Skull base · 2021Article
- The benefits of inferolateral transtubercular route on intradural surgical exposure using the endoscopic endonasal transclival approach.Acta neurochirurgica · 2021Article
- Current Management and Image Review of Skull Base Chordoma: What the Radiologist Needs to Know.Journal of clinical imaging science · 2021Review
- Radiation therapy strategies for skull-base malignancies.Journal of neuro-oncology · 2020Review
- The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review.Frontiers in oncology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChordoma located in the skull base is usually a challenging surgical condition. It is often not possible to achieve gross total resection. Residual tumors have been treated with adjuvant focal radiation therapy employing high-energy particles most commonly through proton beam. In this review, we systematically analyzed indications and outcomes of this treatment with respect to local control rates of the lesion and factors determining recurrence of skull base chordomas. In addition, we collected data on treatment-associated radiation-induced side effects.
methodsIn line with the PRISMA guidelines, the authors performed a literature search algorithm for relevant articles using three databases: PubMed, Embase, and Cochrane. Inclusion and exclusion criteria were applied to evaluate all identified studies published between 1980 and 2018.
resultsOur review included 11 studies for analysis (
conclusionDespite advances in proton therapy, recurrence rates in skull base chordoma remain high. The toxicity of proton therapy may be more prevalent than generally thought. Unfortunately, there is substantial variation in the methods of data reporting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.