Evidence map›Paper›PMID 31528351›Full record

ArticleEnvironmental science. Nano2019

Emerging investigator series: characterization of silver and silver nanoparticle interactions with zinc finger peptides.

Grace Park, Zoe N Amaris, Madeline K Eiken, Karl V Baumgartner, Kathryn A Johnston, Mari A Williams, Jasmine G Markwordt, Jill E Millstone, Kathryn E Splan, Korin E Wheeler

Open access · greenAbstract read
In one paragraph

Article in Environmental science. Nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Disruption of zinc (II) binding and dimeric protein structure of the XIAP-RING domain by copper (I) ions.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Structures of Silver Fingers and a Pathway to Their Genotoxicity.Angewandte Chemie (International ed. in English) · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Grace ParkDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Zoe N AmarisDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Madeline K EikenDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Karl V BaumgartnerDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Kathryn A JohnstonDepartment of Chemistry, University of Pittsburgh, 219 Parkman Ave, Pittsburgh, PA 15260, USA.
Mari A WilliamsDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Jasmine G MarkwordtDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Jill E MillstoneDepartment of Chemistry, University of Pittsburgh, 219 Parkman Ave, Pittsburgh, PA 15260, USA.
Kathryn E SplanDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, Minnesota 55105, USA.
Korin E WheelerDepartment of Chemistry & Biochemistry Santa Clara University Santa Clara, CA 95053, USA.
Santa Clara University · USUniversity of Pittsburgh · USMacalester College · US

Funding

Peptide probes of nanomaterial protein corona dynamics and biological responseR15ES025929 · NIEHS · SANTA CLARA UNIVERSITY · PI WHEELER, KORIN EVELYN · 2016 to 2016
$374k
NIEHS NIH HHS R15 ES025929
6 · The paper itself

Abstract

In biological systems, chemical and physical transformations of engineered silver nanomaterials (AgENMs) are mediated, in part, by proteins and other biomolecules. Metalloprotein interactions with AgENMs are also central in understanding toxicity and antimicrobial and resistance mechanisms. Despite their readily available thiolate and amine ligands, zinc finger (ZF) peptides have thus far escaped study in reaction with AgENMs and their Ag(I) oxidative dissolution product. We report spectroscopic studies that characterize AgENM and Ag(I) interactions with two ZF peptides that differ in sequence, but not in metal binding ligands: the ZF consensus peptide CP-CCHC and the C-terminal zinc finger domain of HIV-1 nucleocapsid protein p7 (NCp7_C). Both ZF peptides catalyze AgENM (10 and 40 nm, citrate coated) dissolution and agglomeration, two important AgENM transformations that impact bioreactivity. AgENMs and their oxidative dissolution product, Ag(I)(

Identifiers

PMID31528351
PMCPMC6746224
OpenAlexW2964027640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.