ArticleMediterranean journal of hematology and infectious diseases2019
Platelet to Lymphocyte Ratio in Neonates: A Predictor of Early onset Neonatal Sepsis.
Article in Mediterranean journal of hematology and infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Role of complete blood count in the diagnosis of culture-proven neonatal sepsis: a systematic review and meta-analysis.Archives of disease in childhood · 2025Pooled it
- Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- The Utility of Peripheral Blood Leucocyte Ratios as Biomarkers in Neonatal Sepsis: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Diagnostic value of platelet-lymphocyte ratio for pediatric sepsis: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Article
- The predictive value of the ratio of multi-dimensional inflammatory biomarkers in pediatric diseases from the perspective of pro-inflammatory/anti-inflammatory balance: a systematic review.Translational pediatrics · 2026Review
- Evaluation of serum progranulin as a biomarker for early detection of neonatal sepsis in a microbiological context.Scientific reports · 2026Article
- CBC ratios for early sepsis risk stratification in newborns: EOS/LOS versus non-septic controls.BMC pediatrics · 2026Article
- Predictive value of combined detection of blood Urea nitrogen and Neutrophil-to-lymphocyte ratio for identifying severe pneumonia complicated with sepsis in neonates.BMC infectious diseases · 2025Article
- Diagnostic Value of Mean Platelet Volume, Neutrophil-to-Lymphocyte Ratio, and Platelet to Lymphocyte Ratio for Late-Onset Neonatal Sepsis.International journal of preventive medicine · 2025Article
- Diagnostic value of procalcitonin and hemocyte parameters in neonates with bloodstream infection: Role of activated hemocyte-related genes.Pediatric discovery · 2024Article
- Role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in diagnosing neonatal sepsis.Narra J · 2024Article
- Assessment of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic immune-inflammatory index, as diagnostic markers for neonatal sepsis.The Journal of international medical research · 2024Article
- Assessment of inflammatory biomarkers to identify surgical/death necrotizing enterocolitis in preterm infants without pneumoperitoneum.Pediatric surgery international · 2024Article
- Diagnostic significance of complete blood cell count and hemogram-derived markers for neonatal sepsis at Southwest Public Hospitals, Ethiopia.World journal of clinical pediatrics · 2024Article
- Predictive Value of Inflammatory Markers NLR, PLR, APRI, SII, and Liver Function Tests in Systemic Inflammatory Response Syndrome Detection in Full-Term Newborns.Children (Basel, Switzerland) · 2024Article
- Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study.Children (Basel, Switzerland) · 2024Article
- The potential role of heparin-binding protein in neonatal sepsis: research progress.Frontiers in cellular and infection microbiology · 2024Review
- [Prognostic utility of inflammatory indexes in critically ill newborns].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Evaluation of Haematological Parameters and Uric Acid in the Diagnosis of Late Onset Neonatal Sepsis.Cureus · 2023Article
- Tackling Neonatal Sepsis-Can It Be Predicted?International journal of environmental research and public health · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal sepsis (NS) is a common systemic disease that causes morbidity and mortality in newborns. But there is no ideal biomarker that can be used in the early diagnosis of NS. In recent studies, platelet to lymphocyte ratio (PLR) has been reported to play a critical role in the inflammatory process. In this study, we aimed to contribute to the research about whether or not PLR can be used as an early predictor of the diagnosis of NS.
methodsThis retrospective cohort study was conducted among the newborns born in İzmir Buca Maternity and Pediatric Hospital between March 2015-February 2016. During these twelve months, 611 neonates with Early-Onset Sepsis (EOS) were admitted to our neonatal intensive care unit. One hundred and forty-nine neonates with suspected EOS, 67 neonates with proven EOS and 92 healthy neonates were enrolled in the study.
resultsPlatelet to lymphocyte ratio (PLR) values of the three groups were calculated 56.5 ± 17.8 vs. 62.4± 14.9 vs. 15.3 ± 2.1, respectively. PLR values of suspected or proven EOS group were significantly higher than the control group. PLR has AUC 0.89 to 0.93, the cutoff value of 39.5 to 57.7, the sensitivity of 88.9% to 91.3% and specificity of 94.7% to 97.6%, the positive predictive value of 94.3% to 97.4%, and negative predictive value of 88.6% to 91.8% in suspected and proven sepsis diagnosis.
conclusionsOur results suggest that PLR can be used as a parameter in the prediction of neonatal sepsis.
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