Evidence map›Paper›PMID 31528316›Full record

ArticleMediterranean journal of hematology and infectious diseases2019

Pregnancy Loss in Women with HIV is not Associated with HIV Markers: Data from a National Study in Italy, 2001-2018.

Marco Floridia, Giulia Masuelli, Beatrice Tassis, Enrica Tamburrini, Valeria Savasi, Matilde Sansone, Arsenio Spinillo, Giuseppina Liuzzi, Anna Degli Antoni, Serena Dalzero and 6 more

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In one paragraph

Article in Mediterranean journal of hematology and infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 1 country.

Marco FloridiaNational Centre for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Giulia MasuelliDepartment of Obstetrics and Neonatology, Città della Salute e della Scienza Hospital, and University of Turin, Turin, Italy.
Beatrice TassisObstetrics and Gynecology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Enrica TamburriniDepartment of Infectious Diseases, Catholic University and Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Valeria SavasiDepartment of Obstetrics and Gynaecology, Luigi Sacco Hospital and University of Milan, Milan, Italy.
Matilde SansoneDepartment of Neurosciences, Reproductive and Dentistry Science, University Federico II, Naples, Italy.
Arsenio SpinilloDepartment of Obstetrics and Gynaecology, IRCCS S. Matteo, Pavia, Italy.
Giuseppina LiuzziI.N.M.I. Lazzaro Spallanzani, Rome, Italy.
Anna Degli AntoniDepartment of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, Parma, Italy.
Serena DalzeroDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
Laura FranceschettiDepartment of Obstetrics and Gynecology, University of Brescia, Brescia, Italy.
Giuliana SimonazziDepartment of Medical and Surgical Sciences, Policlinico Sant'Orsola-Malpighi and University of Bologna, Bologna, Italy.
Gianpaolo MasoInstitute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Daniela FrancisciClinic of Infectious Diseases, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.
Carmela PinnettiI.N.M.I. Lazzaro Spallanzani, Rome, Italy.
Marina RavizzaDepartment of Obstetrics and Gynaecology, DMSD San Paolo Hospital Medical School, University of Milan, Milan, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITOspedale San Paolo · ITFederico II University Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIRCCS Materno Infantile Burlo Garofolo · ITIstituto Superiore di Sanità · ITLuigi Sacco Hospital · ITOspedale di Parma · ITPoliclinico S.Orsola-Malpighi · ITUniversity of Brescia · ITUniversity of Perugia · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited information on pregnancy loss in women with HIV, and it is still debated whether HIV-related markers may play a role.Objectives: To explore potential risk factors for pregnancy loss in women with HIV, with particular reference to modifiable risk factors and markers of HIV disease.

methodsMulticenter observational study of HIV-positive pregnant women. The main outcome measure was pregnancy loss, including both miscarriage (<22 weeks) and stillbirth (≥22 weeks). Possible associations of pregnancy loss were evaluated in univariate and multivariate analyses.

resultsAmong 2696 eligible pregnancies reported between 2001 and 2018, 226 (8.4%) ended in pregnancy loss (miscarriage 198, 7.3%; stillbirth 28, 1.0%). In multivariate analyses, only older age (adjusted odds ratio [AOR] per additional year of age: 1.079, 95% confidence interval [CI] 1.046-1.113), HIV diagnosis before pregnancy (AOR: 2.533, 95%CI 1.407-4.561) and history of pregnancy loss (AOR: 1.625, 95%CI 1.178-2.243) were significantly associated with pregnancy loss. No significant association with pregnancy loss was found for parity, coinfections, sexually transmitted diseases, hypertension, smoking, alcohol and substance use, CD4 cell count, HIV-RNA viral load, and CDC HIV stage.

conclusionsOlder women and those with a previous history of pregnancy loss should be considered at higher risk of pregnancy loss. The severity of HIV disease and potentially modifiable risk factors did not increase the risk of pregnancy loss.

Indexed as

CD4 cell countHIVMiscarriagePregnancy lossStillbirth

Identifiers

PMID31528316
PMCPMC6736172
OpenAlexW2971054397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.