ArticleJournal of community hospital internal medicine perspectives2019
Where there is sodium there may be sepsis.
Article in Journal of community hospital internal medicine perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Prognostic impact of hypernatremia for septic shock patients in the intensive care unit.World journal of clinical cases · 2025Article
- An adaptive federated learning framework for clinical risk prediction with electronic health records from multiple hospitals.Patterns (New York, N.Y.) · 2024Article
- Renal disease and diabetes increase the risk of failed outpatient management of cellulitic hand infections: a retrospective cohort study.Journal of orthopaedic surgery and research · 2023Article
- Admission Serum Magnesium Levels Is Associated with Short and Long-Term Clinical Outcomes in COVID-19 Patients.Nutrients · 2023Article
- Nomogram Prediction Model of Hypernatremia on Mortality in Critically Ill Patients.Infection and drug resistance · 2023Article
- Sodium Toxicity in the Nutritional Epidemiology and Nutritional Immunology of COVID-19.Medicina (Kaunas, Lithuania) · 2021Article
- Clinical characteristics and predictors of mortality associated with COVID-19 in elderly patients from a long-term care facility.Scientific reports · 2020Observational
- Progression to Severe Hypernatremia in Hospitalized General Medicine Inpatients: An Observational Study of Hospital-Acquired Hypernatremia.Medicina (Kaunas, Lithuania) · 2020Observational
- Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Registry Analysis.Frontiers in endocrinology · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypernatremia affects up to 9% of critically ill patients upon hospital admission, especially in elderly patients with thirst impairment. However, hypernatremia is not entirely explained by fluid imbalance. Recent studies suggest that sodium is an important enhancer of the immune system, raising the question of whether inflammatory states such as sepsis may contribute to hypernatremia. Although sepsis patients with hypernatremia face a greater mortality rate, there is a lack of studies examining a potential association between hypernatremia and sepsis. Motivated by the frequent concurrence of hypernatremia and sepsis observed at an eastern Pennsylvanian community hospital, the current study was conducted to evaluate whether hypernatremia on admission may serve as a potential surrogate marker for sepsis. The medical records of 153 patients with hypernatremia on admission (serum sodium > 145mEq/L) were retrospectively analyzed. The mean age of patients was 81.1. Sepsis was observed in 77.1% of patients, of which 86.2% had dementia. This study demonstrated a positive correlation between hypernatremia on admission and the presence of sepsis. We suggest that the existence of hypernatremia should prompt clinicians to further investigate for sources of infection, especially in the elderly and patients with dementia.
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