ArticleJournal of dental sciences2019
Macrophage phenotypes and Gas6/Axl signaling in apical lesions.
Article in Journal of dental sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
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- Editorial: Development of small molecule inhibitors and antibodies targeting AXL for tumor therapy and infectious disease control.Frontiers in oncology · 2022Article
- Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis.Journal of applied oral science : revista FOB · 2022Article
- NOR-1 immunostain is a good method to confirm the diagnosis of an oral acinic cell carcinoma.Journal of dental sciences · 2021Article
- Pindborg tumor: Not all Congo red-positive amyloid-like areas show apple-green birefringence under polarizing microscope.Journal of dental sciences · 2021Article
- Bilateral fibrolipomas at both lower retromolar pads - case report.Journal of dental sciences · 2021Article
- Langerhans cell histiocytosis in an old man - Case report.Journal of dental sciences · 2021Article
- Oral giant cell fibroma: A report of three cases.Journal of dental sciences · 2021Article
- Oral mucosal melanoma: Case report.Journal of dental sciences · 2020Article
- Florid cemento-osseous dysplasia with concomitant occurrence of two simple bone cysts in the mandible - Case report.Journal of dental sciences · 2020Article
- Necrotizing sialometaplasia - Case report.Journal of dental sciences · 2020Article
- Tunnel' radicular cyst and its management with root canal treatment and periapical surgery: A case report.Clinical case reports · 2020Article
- Oral fibrolipoma - Case report.Journal of dental sciences · 2020Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeMacrophages participate in the periapical inflammation with pro-inflammatory M1 cells and anti-inflammatory M2 cells. Gas6/Axl signal is the responsible pathway for the activation of M1 and polarization of M2. The aim of this study was to compare the number of CD16 MATERIALS AND
methodsTwenty-four cases of granuloma and twenty of cysts were submitted to immunohistochemistry using anti-CD16 and anti-CD206 antibodies for determining M1 and M2 macrophages and investigating the cells with positive Gas6 and Axl expression.
resultsThere were more numerous of M1 macrophages in radicular cysts (175.9 ± 87.7) compared to apical granuloma (116.6 ± 55.8), and M2 macrophages was higher in cysts (204.0 ± 97.6) than granuloma (152.9 ± 64.6). The level of Gas6/Axl expression were similar. There was a significant different in M1 macrophage (P = 0.014) between two diagnosis. In patients with or without root resorption, the number of M1 were 194.6 ± 57.2 compared with 139.1 ± 79.6. The number of M2 were 241.7 ± 81.4 and 164.6 ± 77.1. The expression of Axl was stronger in root resorption patients (191.1 ± 43.6), but the tendency in Gas6 expression was similar. Significant differences were noted in high M2 infiltration and Axl positive lesions.
conclusionIt appears that macrophages associated with significantly higher numbers in radicular cysts than apical granuloma. Meanwhile, macrophages and Axl receptor was intensively expressed in patients with root resorption, related to severe inflammation.
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