ArticleJournal of dental sciences2019
Fak silencing impairs osteogenic differentiation of bone mesenchymal stem cells induced by uniaxial mechanical stretch.
Article in Journal of dental sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Research Progress on Dance Training as a Mechanical Stimulus for the Prevention and Treatment of Osteoporosis: A Narrative Review.International journal of molecular sciences · 2026Review
- Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction.International journal of oral science · 2026Article
- [Advances in mechanotransduction signaling pathways in distraction osteogenesis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- The biological function of integrin-linked kinase on bone formation.Bone reports · 2025Review
- Nf2-FAK signaling axis is critical for cranial bone ossification and regeneration.Nature communications · 2025Article
- In situ osteogenic activation of mesenchymal stem cells by the blood clot biomimetic mechanical microenvironment.Nature communications · 2025Article
- Dental-derived stem cells in tissue engineering: the role of biomaterials and host response.Regenerative biomaterials · 2024Review
- The therapeutic potential of neurofibromin signaling pathways and binding partners.Communications biology · 2023Review
- Mechanotransduction in high aspect ratio nanostructured meta-biomaterials: The role of cell adhesion, contractility, and transcriptional factors.Materials today. Bio · 2022Article
- Article
- Immunomodulatory effects and mechanisms of distraction osteogenesis.International journal of oral science · 2022Review
- A Novel Tension Machine Promotes Bone Marrow Mesenchymal Stem Cell Osteoblastic and Fibroblastic Differentiation by Applying Cyclic Tension.Stem cells international · 2021Article
- Endogenous Mechanisms of Craniomaxillofacial Repair: Toward Novel Regenerative Therapies.Frontiers in oral health · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeMechanical stretch plays a key role in promoting proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) in distraction osteogenesis (DO). A better understanding of how the extracellular biomechanical stimulation is transferred to intracellular signal expression will benefit DO. Focal adhesion kinase (FAK) is a key factor in integrin signaling pathway. However, little is known about the effect of integrin-FAK signaling during the process of stretch induced osteogenic differentiation of BMSCs. MATERIALS AND
methodsA specific short hairpin RNAs (shRNAs) lentiviral expression vector was used to silence
resultsThe results showed that mechanical stretch in control groups significantly induced the osteogenic differentiation of BMSCs with increased ALP activity, expression of RUNX2/
conclusionSilencing of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.