ReviewAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2019
Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria.
Review in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 86 citations in OpenAlex.
- Differential associations of IgG-aFcεRI and IgG-aIgE autoantibodies with clinical phenotypes of type IIb chronic spontaneous urticaria.The World Allergy Organization journal · 2026Article
- Knowledge among primary care physicians on urticaria treatment: Impact of educational interventions.The journal of allergy and clinical immunology. Global · 2026Article
- Approach to urticaria in primary care.Singapore medical journal · 2026Article
- Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond.Yonsei medical journal · 2026Review
- Integrated Transcriptomic Analysis Unveils Hub Genes and Immune Dysregulation in Chronic Spontaneous Urticaria Pathogenesis.Journal of inflammation research · 2026Article
- Can the Control of Chronic Spontaneous Urticaria Symptoms Depend on the Stress-Coping Styles?Diagnostics (Basel, Switzerland) · 2025Article
- Lifetime Age-Stratified Associations of Comorbidities in Chronic Urticaria: A Claims-Based Study of 35,907 Cases.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Association Between Proinflammatory Cytokines IL-6 and TNF-Alpha, Psychological Stress and Chronic Spontaneous Urticaria Severity.International journal of molecular sciences · 2025Article
- Exploring the relationship between menstrual cycle and urticaria: Insights from a cross-sectional study.Asia Pacific allergy · 2025Article
- Article
- Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria.Journal of neuroinflammation · 2025Review
- Bridging the gap through telemedicine: Pilot study on the acceptance and use of teledermatology for urticaria.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
- Sustained control of recalcitrant chronic spontaneous urticaria after initiation of inflammatory airway diseases treatment: two case reports.Journal of medical case reports · 2024Article
- The Alarmin Triad-IL-25, IL-33, and TSLP-Serum Levels and Their Clinical Implications in Chronic Spontaneous Urticaria.International journal of molecular sciences · 2024Article
- A Patient Charter for Chronic Urticaria.Advances in therapy · 2024Article
- Association between serological indicators of past contacts with Herpesviridae and a slower resolution of chronic spontaneous urticaria in children.Croatian medical journal · 2023Observational
- Neuro-Immuno-Psychological Aspects of Chronic Urticaria.Journal of clinical medicine · 2023Review
- Gut Microbiome Composition in Patients with Chronic Urticaria: A Review of Current Evidence and Data.Life (Basel, Switzerland) · 2023Review
- Possibilities of Anxiolytic Therapy in the Elimination of Stress Skin Manifestations: A Case Report.Acta medica Lituanic · 2023Article
- Key genes and immune infiltration in chronic spontaneous urticaria: a study of bioinformatics and systems biology.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic spontaneous urticaria (CSU) is often associated with organ specific autoimmunity but is rarely caused by food allergy. Colourings and preservatives in pre-packaged foods, so called pseudoallergens, have also been implicated. Factors that promote inflammation or reduce anti-inflammatory mechanisms may however, predispose susceptible individuals to CSU. Chronic underlying infection and mental and emotional stress can sometimes precede the onset of CSU and once established can exacerbate the symptoms. There is early evidence of dysbiosis within the gastrointestinal tract in people with CSU and reduced levels of vitamin D are also evident. The latter may be related to the importance of vitamin D3 in increasing T regulatory function which can control a tendency to autoimmunity. It is quite possible that a state of on-going chronic inflammation with reduced anti-oxidant mechanisms may underlie the not infrequent association between CSU and metabolic syndrome. Effective treatment of CSU should involve the use of anti-histamines, intermittent steroids and anti-IgE therapy. For recalcitrant disease immune modulatory therapy has a place. However, talking therapies that reduce stress and anxiety, vitamin D3 supplementation, correction of intestinal dysbiosis and treatment of any chronic infection should also be considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.