Evidence map›Paper›PMID 31527844›Full record

ArticleNature plants2019

Multiple genes recruited from hormone pathways partition maize diterpenoid defences.

Yezhang Ding, Katherine M Murphy, Elly Poretsky, Sibongile Mafu, Bing Yang, Si Nian Char, Shawn A Christensen, Evan Saldivar, Mengxi Wu, Qiang Wang and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature plants, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Article
  3. RSC advances · 2026
    Article
  4. Review
  5. Article
  6. Dynamic diversification of lignan metabolism in sesame via coordinated oxygenation and glucosylation across germination.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yezhang DingSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5903-1870
Katherine M MurphyDepartment of Plant Biology, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-8891-4274
Elly PoretskySection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6116-6827
Sibongile MafuDepartment of Plant Biology, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-8049-8798
Bing YangDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Si Nian CharDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Shawn A ChristensenChemistry Research Unit, Center for Medical, Agricultural, and Veterinary Entomology, US Department of Agriculture-Agricultural Research Service, Gainesville, FL, USA.
Evan SaldivarSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.
Mengxi WuSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.
Qiang WangInstitute of Ecological Agriculture, Sichuan Agricultural University, Chengdu, China.
Lexiang JiInstitute of Bioinformatics, University of Georgia, Athens, GA, USA.
Robert J SchmitzDepartment of Genetics, University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0001-7538-6663
Karl A KremlingDepartment of Plant Breeding and Genetics, Cornell University, Ithaca, NY, USA.
Edward S BucklerDepartment of Plant Breeding and Genetics, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-3100-371X
Zhouxin ShenSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.
Steven P BriggsSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.
Jörg BohlmannMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Andrew SherSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.
Gabriel Castro-FalconCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.
Chambers C HughesCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-7000-6438
Alisa HuffakerSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA.
Philipp ZerbeDepartment of Plant Biology, University of California Davis, Davis, CA, USA.
Eric A SchmelzSection of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA. eschmelz@ucsd.edu.ORCID http://orcid.org/0000-0002-2837-734X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duplication and divergence of primary pathway genes underlie the evolution of plant specialized metabolism; however, mechanisms partitioning parallel hormone and defence pathways are often speculative. For example, the primary pathway intermediate ent-kaurene is essential for gibberellin biosynthesis and is also a proposed precursor for maize antibiotics. By integrating transcriptional coregulation patterns, genome-wide association studies, combinatorial enzyme assays, proteomics and targeted mutant analyses, we show that maize kauralexin biosynthesis proceeds via the positional isomer ent-isokaurene formed by a diterpene synthase pair recruited from gibberellin metabolism. The oxygenation and subsequent desaturation of ent-isokaurene by three promiscuous cytochrome P450s and a new steroid 5α reductase indirectly yields predominant ent-kaurene-associated antibiotics required for Fusarium stalk rot resistance. The divergence and differential expression of pathway branches derived from multiple duplicated hormone-metabolic genes minimizes dysregulation of primary metabolism via the circuitous biosynthesis of ent-kaurene-related antibiotics without the production of growth hormone precursors during defence.

Indexed as

Genes, PlantAscomycotaCytochrome P-450 Enzyme SystemDisease ResistanceDiterpenes, KauraneGenome-Wide Association StudyGibberellinsMetabolic Networks and PathwaysPlant DiseasesPlant Growth RegulatorsZea maysCytochrome P-450 Enzyme SystemDiterpenes, Kauranegibberellic acidGibberellinsPlant Growth Regulators

Identifiers

PMID31527844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.