ArticleNature nanotechnology2019
High-speed imaging of surface-enhanced Raman scattering fluctuations from individual nanoparticles.
Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 174 citations in OpenAlex.
- Molecular Modeling of the Raman and SERS Response of 6‑Mercaptopurine: Tautomerism, Surface Coverage, and Charge Transfer.The journal of physical chemistry. C, Nanomaterials and interfaces · 2026Article
- Next-Generation SERS Probes: Engineering Hotspots, Intelligent Molecular Targeting, and AI-Driven Spectral Analysis for Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Single-Molecule Peptide Discrimination via Flow-Through SERS and Machine Learning.ACS photonics · 2026Article
- Spectral Super-Resolution Colloidal SERS Spectroscopy for Multiplexed Detection of Protein Biomarkers.Nano letters · 2026Article
- Raman identification of single nucleotides flowing through permeable plasmonic films.Nature communications · 2025Article
- High-Speed Raman Readout of Single Polypeptides via Plasmonic Nanopores.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Self-Assembled Three-Dimensional Au Films as Highly Reproducible and "Hotspots"-Rich Substrates for Multiplex SERS Detection.Analytical chemistry · 2025Article
- Quantum vibropolaritonic sensing.Science advances · 2025Article
- Ultrasensitive imaging-based sensor unlocked by differential guided-mode resonance.Nature communications · 2025Article
- A surface chemistry perspective on SERS: revisiting the basics to push the field forward.Chemical Society reviews · 2025Review
- Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media.Nano letters · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- High throughput analysis of rare nanoparticles with deep-enhanced sensitivity via unsupervised denoising.Nature communications · 2025Article
- Deep Learning-Powered Colloidal Digital SERS for Precise Monitoring of Cell Culture Media.bioRxiv : the preprint server for biology · 2025Article
- Celebrating 50 Years of Surface Enhanced Spectroscopy.ACS omega · 2024Article
- Multiplexed SERS Detection of Serum Cardiac Markers Using Plasmonic Metasurfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Impact of Surface Enhanced Raman Spectroscopy in Catalysis.ACS nano · 2024Review
- Article
- Accessible Double Nanohole Raman Tweezer Analysis of Single Nanoparticles.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Plasmonic Gold Prism Array for Digital Surface-Enhanced Raman Spectroscopy Sensing.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of plasmonic hotspots is central to the interpretation of the surface-enhanced Raman scattering (SERS) effect. Although plasmonic hotspots are generally portrayed as static features, single-molecule SERS (SM-SERS) is marked by characteristic time-dependent fluctuations in signal intensity. The origin of those fluctuations can be assigned to a variety of dynamic and complex processes, including molecular adsorption or desorption, surface diffusion, molecular reorientation and metal surface reconstruction. Since each of these mechanisms simultaneously contributes to a fluctuating SERS signal, probing their relative impact in SM-SERS remains an experimental challenge. Here, we introduce a super-resolution imaging technique with an acquisition rate of 800,000 frames per second to probe the spatial and temporal features of the SM-SERS fluctuations from single silver nanoshells. The technique has a spatial resolution of ~7 nm. The images reveal short ~10 µs scattering events localized in various regions on a single nanoparticle. Remarkably, even a fully functionalized nanoparticle was 'dark' more than 98% of the time. The sporadic SERS emission suggests a transient hotspot formation mechanism driven by a random reconstruction of the metallic surface, an effect that dominates over any plasmonic resonance of the particle itself. Our results provide the SERS community with a high-speed experimental approach to study the fast dynamic properties of SM-SERS hotspots in typical room-temperature experimental conditions, with possible implications in catalysis and sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.