ArticleNature chemical biology2019
Versatile biomanufacturing through stimulus-responsive cell-material feedback.
Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Article
- Fabrication of cyborg bacterial cells as living cell-material hybrids using intracellular hydrogelation.Nature protocols · 2024Review
- Accelerating the design of pili-enabled living materials using an integrative technological workflow.Nature chemical biology · 2024Article
- Promotion of plasmid maintenance by heterogeneous partitioning of microbial communities.Cell systems · 2023Article
- Hydrogel-encapsulation to enhance bacterial diagnosis of colon inflammation.Biomaterials · 2023Article
- Periplasmic biomineralization for semi-artificial photosynthesis.Science advances · 2023Article
- Engineering living materials by synthetic biology.Biophysics reviews · 2023Review
- Engineering Cyborg Bacteria Through Intracellular Hydrogelation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- On-demand biomanufacturing through synthetic biology approach.Materials today. Bio · 2023Article
- A de novo matrix for macroscopic living materials from bacteria.Nature communications · 2022Article
- Engineering consortia by polymeric microbial swarmbots.Nature communications · 2022Article
- Engineered Living Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Hierarchy-Assembled Dual Probiotics System Ameliorates Cholestatic Drug-Induced Liver Injury via Gut-Liver Axis Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Modulation of microbial community dynamics by spatial partitioning.Nature chemical biology · 2022Article
- Conformational Freedom and Topological Confinement of Proteins in Biomolecular Condensates.Journal of molecular biology · 2022Review
- Engineered microorganism-based delivery systems for targeted cancer therapy: a narrative review.Biomaterials translational · 2022Review
- Engineered microbial consortia: strategies and applications.Microbial cell factories · 2021Review
- Design patterns for engineering genetic stability.Current opinion in biomedical engineering · 2021Article
- Living fabrication of functional semi-interpenetrating polymeric materials.Nature communications · 2021Article
- Synthetic biology as driver for the biologization of materials sciences.Materials today. Bio · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small-scale production of biologics has great potential for enhancing the accessibility of biomanufacturing. By exploiting cell-material feedback, we have designed a concise platform to achieve versatile production, analysis and purification of diverse proteins and protein complexes. The core of our technology is a microbial swarmbot, which consists of a stimulus-sensitive polymeric microcapsule encapsulating engineered bacteria. By sensing the confinement, the bacteria undergo programmed partial lysis at a high local density. Conversely, the encapsulating material shrinks responding to the changing chemical environment caused by cell growth, squeezing out the protein products released by bacterial lysis. This platform is then integrated with downstream modules to enable quantification of enzymatic kinetics, purification of diverse proteins, quantitative control of protein interactions and assembly of functional protein complexes and multienzyme metabolic pathways. Our work demonstrates the use of the cell-material feedback to engineer a modular and flexible platform with sophisticated yet well-defined programmed functions.
Indexed as
Identifiers
31527836What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.