Evidence map›Paper›PMID 31527815›Full record

ArticleBone marrow transplantation2020

Investigation of TGFB1 -1347C>T variant as a biomarker after allogeneic hematopoietic stem cell transplantation.

Petra Kövy, Nóra Meggyesi, Lívia Varga, Katalin Balassa, András Bors, László Gopcsa, Melinda Paksi, Árpád Bátai, Eszter Vad, János Sinkó and 4 more

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Article in Bone marrow transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Petra KövyLaboratory of Molecular Genetics, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Nóra MeggyesiLaboratory of Molecular Genetics, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Lívia VargaLaboratory of Molecular Genetics, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Katalin BalassaLaboratory of Molecular Genetics, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
András BorsLaboratory of Molecular Genetics, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
László GopcsaDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Melinda PaksiDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Árpád BátaiDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Eszter VadDepartment of Microbiology, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
János SinkóDepartment of Microbiology, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Attila TordaiDepartment of Pathophysiology, Semmelweis University, Budapest, Hungary.
Tamás Masszi3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Péter ReményiDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Hajnalka AndrikovicsLaboratory of Molecular Genetics, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Budapest, Hungary. andrikovics.hajnalka@dpckorhaz.hu.

Funding

Magyar Tudományos Akadémia (Hungarian Academy of Sciences) BO/00579/17/5Magyar Tudományos Akadémia (Hungarian Academy of Sciences) ÚNKP-18-4-SE-11Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal (NKFI Office) NVKP_16-1-2016-0005
6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative therapeutic option for malignant hematopoietic diseases. Cytokines including transforming growth factor β1 (TGFβ1) play a pivotal role in immune reconstruction, and the development of graft versus host disease (GvHD) or infections. The aim of this study was to investigate the role of TGFB1 gene -1347C>T variant in the outcome of HSCT in a cohort of 409 adult recipient-donor pairs. TGFB1 variant was analysed from genomic DNA with LightCycler hybridisation probe method. In case of myeloablative conditioning, donor TGFB1 genotype correlated with overall survival (60-month OS for CC: 62.1 ± 4.8%; CT: 46.8 ± 4.8%; TT: 35.6 ± 9.3%; p = 0.032), which was independent of age, donor type and GvHD prophylaxis in multivariate analysis (HR:2.35, 95%CI:1.35-4.10, p = 0.003). The cumulative incidence of acute GvHD grade III-IV [CC:10%; CT:17%; TT:24%], and non-relapse mortality was higher in TT-carriers (24-month NRM: CC:24%; CT:26%; TT:46%, p = 0.035). We did not find any association between recipient TGFB1 -1347C>T polymorphism and HSCT outcome. Our results suggest that donor TGFB1 -1347C>T may exert an adverse influence on the outcome of myeloablative conditioning transplantation.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationTransforming Growth Factor beta1AdultBiomarkersHumansNeoplasm Recurrence, LocalTransplantation ConditioningTransplantation, HomologousBiomarkersTGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID31527815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.