Evidence map›Paper›PMID 31527806›Full record

ReviewNature reviews. Neurology2019

Post-traumatic headache: epidemiology and pathophysiological insights.

Håkan Ashina, Frank Porreca, Trent Anderson, Faisal Mohammad Amin, Messoud Ashina, Henrik Winther Schytz, David W Dodick

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 116 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 6 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07267819 recruitingnot on this mapstarted 2025, after this paper: background citation

The Efficacy of Xeomin as a Prophylactic Therapy for Migraine in Patients With Traumatic Brain Injuries (TBIs) Versus Anomalous Health Incidents (AHIs)

TypeobservationalSponsorUniformed Services University of the Health SciencesRan2025 to 2028Enrolled60ConditionsMigraine, Traumatic Brain Injury, Anomalous Health IncidentsArmsXeomin (incobotulinumtoxinA)
NCT07340775 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Hypersensitivity to Amylin in Post-Traumatic Headache: A Randomized Clinical Trial

TypeinterventionalSponsorDanish Headache CenterRan2026 to 2028Enrolled21ConditionsHeadache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System DiseasesArmsAmylin, Placebo
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 6 syntheses or guidelines pooled it, 225 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
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  6. Pooled it
  7. Trial
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  9. Hypersensitivity to BKThe journal of headache and pain · 2024
    Trial
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  15. Observational
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Håkan AshinaDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Frank PorrecaDepartment of Pharmacology, University of Arizona, Tucson, Phoenix, AZ, USA.
Trent AndersonDepartment of Basic Medical Sciences, University of Arizona, Phoenix, AZ, USA.
Faisal Mohammad AminDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Messoud AshinaDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Henrik Winther SchytzDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
David W DodickDepartment of Neurology, Mayo Clinic, Phoenix, AZ, USA. Dodick.David@mayo.edu.
University of Arizona · USUniversity of Copenhagen · DKGlostrup Hospital · DKMayo Clinic Hospital · USRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one of the most common sequelae of mild traumatic brain injury, also known as concussion. Considerable overlap exists between PTH and common primary headache disorders. The most common PTH phenotypes are migraine-like headache and tension-type-like headache. A better understanding of the pathophysiological similarities and differences between primary headache disorders and PTH could uncover unique treatment targets for PTH. Although possible underlying mechanisms of PTH have been elucidated, a substantial void remains in our understanding, and further research is needed. In this Review, we describe the evidence from animal and human studies that indicates involvement of several potential mechanisms in the development and persistence of PTH. These mechanisms include impaired descending modulation, neurometabolic changes, neuroinflammation and activation of the trigeminal sensory system. Furthermore, we outline future research directions to establish biomarkers involved in progression from acute to persistent PTH, and we identify potential drug targets to prevent and treat persistent PTH.

Indexed as

AnimalsBrain Injuries, TraumaticHumansPost-Traumatic Headache

Identifiers

PMID31527806
OpenAlexW2972362438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.