Evidence map›Paper›PMID 31527743›Full record

ReviewNature reviews. Cardiology2020

Expanding the indications for transcatheter aortic valve implantation.

Zouhair Rahhab, Nahid El Faquir, Didier Tchetche, Victoria Delgado, Susheel Kodali, E Mara Vollema, Jeroen Bax, Martin B Leon, Nicolas M Van Mieghem

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Review
  7. Article
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  9. Article
  10. Article
  11. TAVI Through the Years: A Systematic Review of Progress.Journal of pharmacy & bioallied sciences · 2025
    Review
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zouhair RahhabDepartment of Cardiology, Erasmus Medical Center, Thoraxcenter, Rotterdam, Netherlands.
Nahid El FaquirDepartment of Cardiology, Erasmus Medical Center, Thoraxcenter, Rotterdam, Netherlands.
Didier TchetcheDepartment of Cardiology, Clinique Pasteur, Toulouse, France.
Victoria DelgadoDepartment of Cardiology, Leiden University Center, Leiden, Netherlands.ORCID http://orcid.org/0000-0002-9841-2737
Susheel KodaliDepartment of Cardiology, Columbia University Medical Center, New York, NY, USA.
E Mara VollemaDepartment of Cardiology, Leiden University Center, Leiden, Netherlands.ORCID http://orcid.org/0000-0002-6087-8865
Jeroen BaxDepartment of Cardiology, Leiden University Center, Leiden, Netherlands.
Martin B LeonDepartment of Cardiology, Columbia University Medical Center, New York, NY, USA.
Nicolas M Van MieghemDepartment of Cardiology, Erasmus Medical Center, Thoraxcenter, Rotterdam, Netherlands. n.vanmieghem@erasmusmc.nl.ORCID http://orcid.org/0000-0002-2732-1205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of symptomatic severe aortic valve stenosis. Current guidelines recommend TAVI in patients at increased operative risk of death. Advanced imaging planning, new transcatheter valve platforms, procedure streamlining and growing operator experience have improved procedural safety and bioprosthetic valve performance. As a result, TAVI has been explored for other indications. Two randomized trials published in 2019 to assess TAVI in patients with symptomatic severe aortic stenosis at low operative risk have set the stage for a new wave of indications. In younger and low-risk patients, TAVI had an early safety benefit over surgical aortic valve replacement and was associated with faster discharge from hospital and recovery and fewer rehospitalizations. In patients with symptomatic severe aortic stenosis, TAVI has now been explored across the entire spectrum of operative risk, from inoperable to low-risk populations, in properly designed, randomized clinical trials, although data on the long-term durability of these valves are lacking. The use of TAVI in severe bicuspid aortic valve stenosis, asymptomatic severe aortic stenosis, moderate aortic stenosis in combination with heart failure with reduced ejection fraction, and isolated pure aortic regurgitation is now under investigation in clinical trials. In this Review, we provide our perspective on these evolving indications for TAVI, discuss relevant available data from clinical trials, and highlight procedural implications and caveats of new and future indications.

Indexed as

Transcatheter Aortic Valve ReplacementAge FactorsAortic ValveAortic Valve InsufficiencyAortic Valve StenosisHumansPatient SelectionRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment Outcome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.