Evidence map›Paper›PMID 31527483›Full record

ReviewNanomaterials (Basel, Switzerland)2019

Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging.

Febrina Sandra, Nisar Ul Khaliq, Anwar Sunna, Andrew Care

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Review
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  4. Sericin-coated MnOScientific reports · 2025
    Article
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  16. mRNA delivery in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2023
    Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Febrina SandraDepartment of Molecular Sciences, Macquarie University, Sydney 2109, Australia. febrina.sandra@hdr.mq.edu.au.
Nisar Ul KhaliqCollege of Pharmacy, Korea University, 2511 Sejong-ro, Sejong 30019, Korea. nisul151@korea.ac.kr.
Anwar SunnaDepartment of Molecular Sciences, Macquarie University, Sydney 2109, Australia. anwar.sunna@mq.edu.au.ORCID 0000-0002-1467-9937
Andrew CareDepartment of Molecular Sciences, Macquarie University, Sydney 2109, Australia. andrew.care@mq.edu.au.ORCID 0000-0002-0035-7961

Funding

ARC Centre of Excellence for Nanoscale BioPhotonics CE140100003Cancer Institute NSW ECF171114Commonwealth Scientific and Industrial Research Organisation 50068016
6 · The paper itself

Abstract

In recent years, it has become apparent that cancer nanomedicine's reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their "bio-nano" interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.

Indexed as

cancer imagingcancer therapydrug deliverynanomedicineprotein-based nanoparticlessynthetic biologyvirus-like particles

Identifiers

PMID31527483
PMCPMC6781024

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.