Loosening of Side-Chain Packing Associated with Perturbations in Peripheral Dynamics Induced by the D76N Mutation of β

Kazumasa Sakurai, Ryosuke Tomiyama, Takuma Shiraki, Yasushige Yonezawa

Abstract read

In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Disease-relevant βNature communications · 2023
Article
Pathogenic D76N Variant of βBiology · 2021
Article
The Early Phase of β2-Microglobulin Aggregation: Perspectives From Molecular Simulations.Frontiers in molecular biosciences · 2020
Review
Enhanced accessibility and hydrophobicity of amyloidogenic intermediates of the β2-microglobulin D76N mutant revealed by high-pressure experiments.The Journal of biological chemistry
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kazumasa SakuraiHigh Pressure Protein Research Center, Institute of Advanced Technology, Kindai University, 930 Nishimitani, Kinokawa, Wakayama 649-6493, Japan. sakurai@waka.kindai.ac.jp.ORCID 0000-0001-6420-7148

Ryosuke TomiyamaGraduate School of Biology-Oriented Science and Technology, Kindai University, Wakayama 649-6493, Japan. 1933710005g@waka.kindai.ac.jp.

Takuma ShirakiDepartment of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama 649-6493, Japan. shiraki@waka.kindai.ac.jp.ORCID 0000-0003-3186-9588

Yasushige YonezawaHigh Pressure Protein Research Center, Institute of Advanced Technology, Kindai University, 930 Nishimitani, Kinokawa, Wakayama 649-6493, Japan. yonezawa-wk@waka.kindai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Indexed as

Amino Acid Substitutionbeta 2-MicroglobulinCrystallography, X-RayHumansModels, MolecularMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularPressureProtein AggregatesProtein Conformation, beta-StrandProtein FoldingB2M protein, humanbeta 2-MicroglobulinProtein Aggregatesamyloid fibrilHigh pressure experimentMD simulationNMRβ2-microglobulin

Identifiers

PMID31527472

DOI10.3390/biom9090491

PMCPMC6769805

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.