Evidence map›Paper›PMID 31527432›Full record

ArticleMarine drugs2019

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from

Steve Peigneur, Prabha Devi, Andrea Seldeslachts, Samuthirapandian Ravichandran, Loïc Quinton, Jan Tytgat

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Steve PeigneurToxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. steve.peigneur@pharm.kuleuven.be.ORCID 0000-0003-0504-5702
Prabha DeviToxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. dprabha@nio.org.
Andrea SeldeslachtsToxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. andrea.seldeslachts@gmail.com.
Samuthirapandian RavichandranCenter of Advanced Study in Marine Biology, Annamalai University, Parangipettai, Tamil Nadu 608 502, India. sravicas@gmail.com.
Loïc QuintonLaboratory of Mass Spectrometry, Department of Chemistry, University of Liège, 4000 Liège, Belgium. loic.quinton@uliege.be.ORCID 0000-0001-8153-9590
Jan TytgatToxicology and Pharmacology, KU Leuven, Campus Gasthuisberg, O & N2, Herestraat 49, P.O. Box 922, 3000 Leuven, Belgium. jan.tytgat@kuleuven.be.
KU Leuven · BEAnnamalai University · INNational Institute of Oceanography · INUniversity of Liège · BE

Funding

EMBO ESTF7241Fonds Wetenschappelijk Onderzoek GOA4919NFonds Wetenschappelijk Onderzoek GOC2319NKU Leuven CELSA/17/047KU Leuven PDM/19/164
6 · The paper itself

Abstract

The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs). Because nAChRs have an important role in regulating transmitter release, cell excitability, and neuronal integration, nAChR dysfunctions have been implicated in a variety of severe pathologies. We describe the isolation and characterization of α-conotoxin MilIA, the first conopeptide from the venom of

Indexed as

Amino Acid SequenceAnimalsConotoxinsConus SnailMutationNeurotoxinsNicotinic AntagonistsOocytesPatch-Clamp TechniquesPeptidesReceptors, NicotinicRecombinant ProteinsStructure-Activity RelationshipXenopus laevisConotoxinsNeurotoxinsNicotinic AntagonistsPeptidesReceptors, NicotinicRecombinant Proteinscone snail toxinsconopeptidedrug developmentelectrophysiologyion channel diseasesnicotinic acetylcholine receptorα-conotoxin

Identifiers

PMID31527432
PMCPMC6780063
OpenAlexW2972800380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.