ArticleNeurology2019
Pediatric postoperative cerebellar cognitive affective syndrome follows outflow pathway lesions.
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Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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53citing papers in PubMed, 1 pooled it
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53 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
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- Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Fatimah M AlbazronFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0003-2053-3528
Joel BrussFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0003-2415-1658
Robin M JonesFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.
Torunn I YockFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0001-6408-8011
Margaret B PulsiferFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0003-3160-4846
Alexander L CohenFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0001-6557-5866
Peg C NopoulosFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.ORCID 0000-0001-8810-1903
Annah N AbramsFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.
Mariko SatoFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA.
Aaron D BoesFrom the Neuroimaging and Noninvasive Brain Stimulation Laboratory (F.M.A., J.B., A.D.B.), Departments of Pediatrics, Neurology, and Psychiatry, University of Iowa Hospitals and Clinics, Iowa City; Department of Pediatric Neurology (R.M.J.), Department of Radiation Oncology (T.I.Y.), Department of Psychiatry (M.B.P.), and Department of Child and Adolescent Psychiatry and Pediatric Hematology Oncology (A.N.A.), Massachusetts General Hospital; Department of Neurology (A.L.C.), Boston Children's Hospital, MA; Department of Psychiatry (P.C.N.), University of Iowa Hospitals and Clinics, Iowa City; and Department of Pediatric Hematology Oncology (M.S.), Stead Family Children's Hospital, Iowa City, IA. aaron-boes@uiowa.edu.ORCID 0000-0002-7865-9257
Boston Children's Hospital · US
Funding
Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2MMolecular and Cellular Research to Advance Childhood HealthK12HD027748 · NICHD · UNIVERSITY OF IOWA · PI ALEXANDER G BASSUK · 2002 to 2026
$9.2MTranslational Post-doctoral Training in NeurodevelopmentT32MH112510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI DAVID C GLAHN, CHARLES Alexander NELSON · 2017 to 2026
$2.6MNICHD NIH HHS K12 HD027748NIMH NIH HHS T32 MH112510NINDS NIH HHS K12 NS098482
Abstract
objectiveTo evaluate lesion location after pediatric cerebellar tumor resection in relation to the development of severe cognitive and affective disturbances, or cerebellar cognitive affective syndrome (CCAS).
methodsThe postsurgical lesion location of 195 pediatric patients with cerebellar tumors was mapped onto a template brain. Individuals with CCAS were matched to 2 participants without CCAS by sex, age, and lesion volume. Lesion analyses included both a hypothesis-driven evaluation of the cerebellar outflow pathway (deep nuclei and superior cerebellar peduncles) and data-driven multivariate lesion symptom mapping. Lesion-associated networks were evaluated by comparing connectivity patterns between the lesion location of cases with and those without CCAS with resting-state functional connectivity MRI data from large normative adult and pediatric cohorts.
resultsCCAS was present in 48 of 195 participants (24.6%) and was strongly associated with cerebellar outflow tract lesions (
conclusionLesions of the cerebellar outflow pathway and inferior vermis are associated with major cognitive and affective disturbances after pediatric cerebellar tumor resection, and disrupted communication between the cerebellum and the thalamic mediodorsal nucleus may be important.
Indexed as
Postoperative PeriodAdolescentAdultBrainCerebellar DiseasesCerebellumChildCognitionCognition DisordersFemaleHumansMaleYoung Adult
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