Evidence map›Paper›PMID 31527256›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Identification of

Taiyi Kuo, Michael J Kraakman, Manashree Damle, Richard Gill, Mitchell A Lazar, Domenico Accili

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
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  10. Review
  11. Insulin resistance in type 2 diabetes mellitus.Nature reviews. Endocrinology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. FOXO1 regulates expression of Neurod4 in the pituitary gland.Molecular and cellular endocrinology · 2024
    Article
  17. Article
  18. Editorial: Pancreatic beta-cell dedifferentiation.Frontiers in endocrinology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Taiyi KuoDepartment of Medicine, Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Michael J KraakmanDepartment of Medicine, Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Manashree DamleThe Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Richard GillDepartment of Medicine, Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Mitchell A LazarThe Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; lazar@pennmedicine.upenn.edu da230@cumc.columbia.edu.ORCID 0000-0001-8653-1280
Domenico AcciliDepartment of Medicine, Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, NY 10032; lazar@pennmedicine.upenn.edu da230@cumc.columbia.edu.
Columbia University · USUniversity of Pennsylvania · US

Funding

Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Anthony W Ferrante · 2003 to 2026
$36.7M
MECHANISMS OF BETA CELL FAILURER01DK064819 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ACCILI, DOMENICO · 2003 to 2025
$10.5M
Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
Epigenetic Regulation by FoxO1 in Pancreatic Beta CellsK01DK114372 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KUO, TAIYI DIANA · 2018 to 2021
$693k
NIDDK NIH HHS K01 DK114372NIDDK NIH HHS P30 DK063608NIDDK NIH HHS R01 DK064819NIDDK NIH HHS T32 DK007328
6 · The paper itself

Abstract

Fine mapping and validation of genes causing β cell failure from susceptibility loci identified in type 2 diabetes genome-wide association studies (GWAS) poses a significant challenge. The

Indexed as

Genetic Predisposition to DiseaseGenetic VariationAnimalsBase SequenceBinding SitesBiomarkersConserved SequenceDiabetes Mellitus, Type 2Enhancer Elements, GeneticForkhead Box Protein O1Genetic Association StudiesHumansInsulinInsulin-Secreting CellsMiceModels, BiologicalBiomarkersC2CD4A protein, humanForkhead Box Protein O1FOXO1 protein, humanInsulinNuclear ProteinsTranscription FactorsC2cd4adiabetesepigeneticsFoxO1GWAS

Identifiers

PMID31527256
PMCPMC6778232
OpenAlexW2974663518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.