ArticleProceedings of the National Academy of Sciences of the United States of America2019
Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Epigenetics-mediated pathological alterations and their diagnostic and therapeutic potential in sepsis-associated acute kidney injury.Clinical epigenetics · 2026Review
- Virulence Phenotypes Differentiate Persistent vs. Resolving Isolates of HumanAntibiotics (Basel, Switzerland) · 2026Article
- Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment.Nature reviews. Microbiology · 2026Review
- Comparative Tumor Microenvironment Analysis for HCC and PDAC Using KMplotter.International journal of molecular sciences · 2025Article
- Staphylococcus aureus α-hemolysin induces DNA methylation changes in human Th1 cells.Immunologic research · 2025Article
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- The lack of a biorepository during vaccine trials: A lost opportunity to understand staphylococcal immunity.Vaccine · 2025Article
- Multi-omics decodes host-specific and environmental microbiome interactions in sepsis.Frontiers in microbiology · 2025Review
- The Purine Biosynthesis Repressor, PurR, Contributes to Vancomycin Susceptibility of Methicillin-resistant Staphylococcus aureus in Experimental Endocarditis.The Journal of infectious diseases · 2024Article
- Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs.PNAS nexus · 2024Article
- Integrated transcriptomic analysis reveals immune signatures distinguishing persistent versus resolving outcomes in MRSA bacteremia.Frontiers in immunology · 2024Article
- Risk Factors and Outcomes of Hematogenous Vertebral Osteomyelitis in Patients With Staphylococcus aureus Bacteremia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Black and White Patients With Staphylococcus aureus Bacteremia Have Similar Outcomes but Different Risk Factors.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Persistent Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies.The Journal of infection · 2023Article
- MRSA Isolates from Patients with Persistent Bacteremia Generate Nonstable Small Colony VariantsInfection and immunity · 2023Article
- Article
- Review
- Bacterial DNA involvement in carcinogenesis.Frontiers in cellular and infection microbiology · 2022Review
- An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration.Genome medicine · 2021Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Felix Mba MedieDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710.
Batu K Sharma-KuinkelDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710.
Felicia RuffinDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710.
Liana C ChanDivision of Molecular Medicine, Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502.ORCID 0000-0003-2567-4418
Maura RossettiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles Immunogenetics Center, Los Angeles, CA 90095.
Yu-Ling ChangDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles Immunogenetics Center, Los Angeles, CA 90095.
Lawrence P ParkDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710.
Arnold S BayerDivision of Infectious Diseases, Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502.
Scott G FillerDivision of Infectious Diseases, Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502.ORCID 0000-0001-7278-3700
Richard AhnDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles Immunogenetics Center, Los Angeles, CA 90095.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles Immunogenetics Center, Los Angeles, CA 90095.
David GjertsonDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles Immunogenetics Center, Los Angeles, CA 90095.
Michael R YeamanDivision of Molecular Medicine, Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90502.
Vance G FowlerDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC 27710; Vance.Fowler@duke.edu.ORCID 0000-0002-8048-0897
MRSA Systems Immunobiology Group
University of California, Los Angeles · USDuke University · USQB3 · US
Funding
Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1MHost Susceptibility to S. aureusR01AI068804 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2007 to 2016
$6.9MMentoring Patient Oriented Research in Antibiotic-Resistant BacteriaK24AI093969 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2011 to 2020
$1.6MMitigating Resistance & Virulence in MRSAR33AI111661 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2018
$1.2MNIAID NIH HHS K24 AI093969NIAID NIH HHS R01 AI068804NIAID NIH HHS R33 AI111661NIAID NIH HHS U01 AI124319
Abstract
The role of the host in development of persistent methicillin-resistant
Indexed as
Genetic Predisposition to DiseaseGenetic VariationMethicillin-Resistant Staphylococcus aureusAgedBacteremiaComorbidityCpG IslandsDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3AFemaleGenotypeHost-Pathogen InteractionsHumansInterleukin-10MacrophagesDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanInterleukin-10DNMT3Ahost geneticsMRSApersistenceStaphylococcus aureus
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.