ArticleProceedings of the National Academy of Sciences of the United States of America2019
Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Effect of muscarinic blockade on the speed of attention shifting, read-out delays and learning.Psychopharmacology · 2025Trial
- Nicotine causes highly localized and tuned changes in thalamocortical gain that cascade strongly and selectively through the cortical circuit.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Preoperative Cholinergic Signatures Drive Segregated Brain Architecture in Postoperative Delirium.Research square · 2025Article
- Functional role of cell classes in monkey prefrontal cortex after learning a working memory task.Communications biology · 2025Article
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- Article
- Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cholinergic Neuromodulation of Prefrontal Attractor Dynamics Controls Performance in Spatial Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Cholinergic neuromodulation of prefrontal attractor dynamics controls performance in spatial working memory.bioRxiv : the preprint server for biology · 2024Article
- Pathway-selective optogenetics reveals the functional anatomy of top-down attentional modulation in the macaque visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Improving Visual Working Memory with Cholinergic Deep Brain Stimulation.Brain sciences · 2023Review
- MProceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Ripples in macaque V1 and V4 are modulated by top-down visual attention.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Muscarinic antagonists impair multiple aspects of operant discrimination learning and performance.Neuroscience letters · 2023Article
- Dopamine influences attentional rate modulation in Macaque posterior parietal cortex.Scientific reports · 2022Article
- The diversity and specificity of functional connectivity across spatial and temporal scales.NeuroImage · 2021Review
- Cholinergic modulation of sensory processing in awake mouse cortex.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Attention is critical to high-level cognition, and attentional deficits are a hallmark of cognitive dysfunction. A key transmitter for attentional control is acetylcholine, but its cellular actions in attention-controlling areas remain poorly understood. Here we delineate how muscarinic and nicotinic receptors affect basic neuronal excitability and attentional control signals in different cell types in macaque frontal eye field. We found that broad spiking and narrow spiking cells both require muscarinic and nicotinic receptors for normal excitability, thereby affecting ongoing or stimulus-driven activity. Attentional control signals depended on muscarinic, not nicotinic receptors in broad spiking cells, while they depended on both muscarinic and nicotinic receptors in narrow spiking cells. Cluster analysis revealed that muscarinic and nicotinic effects on attentional control signals were highly selective even for different subclasses of narrow spiking cells and of broad spiking cells. These results demonstrate that cholinergic receptors are critical to establish attentional control signals in the frontal eye field in a cell type-specific manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.