ArticleProceedings of the National Academy of Sciences of the United States of America2019
Genomic analysis of siderophore β-hydroxylases reveals divergent stereocontrol and expands the condensation domain family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- PhyloNaP: a user-friendly database of phylogeny for natural product-producing enzymes.Bioinformatics (Oxford, England) · 2026Article
- Genome Mining Guided Identification of the Metallophore Delftichelin A fromJournal of natural products · 2026Article
- Total Synthesis and Functional Analysis of Loihichelin C: Structural Basis for Mn(III) Stabilization and Mn(II) Oxidation.JACS Au · 2026Article
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- Lactuchelins represent lipopeptide siderophores produced by Pseudomonas lactucae that inhibit Xanthomonas campestris.The ISME journal · 2026Article
- Cyanochelin B: a cyanobacterium-produced siderophore with photolytic properties that negate iron monopolization in UV light.Applied and environmental microbiology · 2025Article
- antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation.Nucleic acids research · 2025Article
- Structure of a putative terminal amidation domain in natural product biosynthesis.Structure (London, England : 1993) · 2025Article
- Bokeelamides: Lipopeptides from Bacteria Associated with Marine Egg Masses.Organic letters · 2024Article
- LCMS-Metabolomic Profiling and Genome Mining ofJournal of natural products · 2024Article
- SIDERITE: Unveiling hidden siderophore diversity in the chemical space through digital exploration.iMeta · 2024Article
- New variochelins from soil-isolatedBeilstein journal of organic chemistry · 2024Article
- Tistrellabactins A and B Are PhotoreactiveJournal of natural products · 2023Article
- Knowledge-guided data mining on the standardized architecture of NRPS: Subtypes, novel motifs, and sequence entanglements.PLoS computational biology · 2023Article
- Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases.Engineering microbiology · 2023Review
- Comparative metabolomic profiling ofFrontiers in chemistry · 2023Article
- Shipworm symbiosis ecology-guided discovery of an antibiotic that kills colistin-resistant Acinetobacter.Cell chemical biology · 2021Article
- Article
- Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin.Angewandte Chemie (International ed. in English) · 2021Article
- Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity.Nature communications · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome mining of biosynthetic pathways streamlines discovery of secondary metabolites but can leave ambiguities in the predicted structures, which must be rectified experimentally. Through coupling the reactivity predicted by biosynthetic gene clusters with verified structures, the origin of the β-hydroxyaspartic acid diastereomers in siderophores is reported herein. Two functional subtypes of nonheme Fe(II)/α-ketoglutarate-dependent aspartyl β-hydroxylases are identified in siderophore biosynthetic gene clusters, which differ in genomic organization-existing either as fused domains (IβH
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