Evidence map›Paper›PMID 31527226›Full record

ArticleMolecular cancer therapeutics2019

Ketotifen Modulates Mast Cell Chemotaxis to Kit-Ligand, but Does Not Impact Mast Cell Numbers, Degranulation, or Tumor Behavior in Neurofibromas of

Ciersten A Burks, Steven D Rhodes, Waylan K Bessler, Shi Chen, Abbi Smith, Jeffrey R Gehlhausen, Eric T Hawley, Li Jiang, Xiaohong Li, Jin Yuan and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  2. TheCancers · 2024
    Review
  3. Article
  4. Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  5. Review
  6. Review
  7. [Treatment and progress of cutaneous neurofibroma].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Ciersten A BurksHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Steven D RhodesHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Waylan K BesslerHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Shi ChenHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Abbi SmithHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Jeffrey R GehlhausenHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Eric T HawleyHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Li JiangHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Xiaohong LiHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Jin YuanHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Qingbo LuHerman B. Wells Center for Pediatric Research, Indianapolis, Indiana.
Max JacobsenDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
George E SanduskyDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
David R JonesDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
D Wade Clapp *Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana. dclapp@iu.edu jblakel3@jhmi.edu.
Jaishri O Blakeley *Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland. dclapp@iu.edu jblakel3@jhmi.edu.
Indiana University – Purdue University Indianapolis · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Sara K Quinney · 1999 to 2026
$59.3M
Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Project 4: Secondary Cancers Among NF1 Cancer SurvivorsU54CA196519 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Yunlong Liu · 2015 to 2026
$26.9M
NCI NIH HHS P30 CA082709NCI NIH HHS U54 CA196519NICHD NIH HHS K12 HD000850
6 · The paper itself

Abstract

Neurofibromatosis Type 1 (NF1) is one of the most common genetic tumor predisposition syndromes in humans. Mutant

Indexed as

AnimalsChemotaxisHistamine H1 AntagonistsKetotifenMast CellsMiceNeurofibromaNeurofibromin 1Stem Cell FactorHistamine H1 AntagonistsKetotifenNeurofibromin 1Stem Cell Factor

Identifiers

PMID31527226
PMCPMC7482139
OpenAlexW2973581767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.