Evidence map›Paper›PMID 31527128›Full record

ArticleInfection and immunity2019

Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence.

Lucia Xiang, Maria Fernanda Laranjeira-Silva, Fernando Y Maeda, Jason Hauzel, Norma W Andrews, Bidyottam Mittra

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Molecular Mechanisms of Drug Resistance inPathogens (Basel, Switzerland) · 2024
    Review
  4. Heme metabolism in Strigomonas culicis: Implications of HThe Journal of biological chemistry · 2024
    Article
  5. Review
  6. Nitric Oxide Resistance inAntioxidants (Basel, Switzerland) · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lucia XiangDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Maria Fernanda Laranjeira-SilvaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Fernando Y MaedaDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Jason HauzelDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Norma W AndrewsDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Bidyottam MittraDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA bmittra@umd.edu.
University of Maryland, College Park · USUniversidade de São Paulo · BR

Funding

Molecular Determinants of Intracellular Survival and Replication in LeishmaniaR01AI067979 · NIAID · YALE UNIVERSITY · PI ANDREWS, NORMA WINDSOR · 2007 to 2018
$3.8M
NIAID NIH HHS R01 AI067979
6 · The paper itself

Abstract

The molecular mechanisms underlying biological differences between two

Indexed as

AnimalsAscorbate PeroxidasesCells, CulturedLeishmania majorLeishmania mexicanaLeishmaniasis, CutaneousMacrophagesMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesVirulenceAscorbate PeroxidasesReactive Oxygen Speciesascorbate-dependent peroxidasedifferentiationLeishmaniamitochondriaredox signaling

Identifiers

PMID31527128
PMCPMC6867856
OpenAlexW2973765197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.