Evidence map›Paper›PMID 31527021›Full record

ArticleAntimicrobial agents and chemotherapy2019

CTX-M-33, a CTX-M-15 derivative conferring reduced susceptibility to carbapenems.

Laurent Poirel, José-Manuel Ortiz de la Rosa, Anaïs Richard, Marta Aires-de-Sousa, Patrice Nordmann

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Characterization of BAS-1, a novel class A β-lactamase encoded inAntimicrobial agents and chemotherapy · 2026
    Article
  2. Article
  3. Carbapenem resistance in aAntimicrobial agents and chemotherapy · 2025
    Article
  4. Article
  5. Carbapenem Resistance inMicroorganisms · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Co-resistance to ceftazidime-avibactam and cefiderocol in clinical isolates producing KPC variants.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Article
  12. Genome-wide association study ofFrontiers in microbiology · 2022
    Article
  13. Intestinal colonization with ESBL-producingFrontiers in public health · 2022
    Article
  14. Review
  15. Article
  16. Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.Antimicrobial agents and chemotherapy · 2021
    Article
  17. Review
  18. Prevalence, serotyping and drug susceptibility patterns ofWorld journal of biological chemistry · 2020
    Article
  19. Antimicrobial agents and chemotherapy · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laurent PoirelEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg laurent.poirel@unifr.ch.
José-Manuel Ortiz de la RosaEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg.
Anaïs RichardEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg.
Marta Aires-de-SousaEscola Superior de Saúde da Cruz Vermelha Portuguesa (ESSCVP), Lisbon, Portugal.
Patrice NordmannEmerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CTX-M-type extended-spectrum ß-lactamases (ESBL) are widespread among Enterobacterales worldwide. The most common variant is CTX-M-15 hydrolyzing ceftazidime at high rate, but sparing carbapenems. We identified here CTX-M-33, a point mutant derivative of CTX-M-15 (Asp to Ser substitution at Ambler position 109), exhibiting a low carbapenemase activity. ß-Lactamase CTX-M-33 was identified in a

Identifiers

PMID31527021
PMCPMC6879240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.