ArticleAmerican journal of ophthalmology2020
Detection of Reduced Retinal Vessel Density in Eyes with Geographic Atrophy Secondary to Age-Related Macular Degeneration Using Projection-Resolved Optical Coherence Tomography Angiography.
Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- OCT angiography-derived biomarkers of retinal and choroidal microvascular changes in dry age-related macular degeneration.Medicine · 2026Article
- Article
- Retinal Vessel Coronal Displacement in Intermediate Age-Related Macular Degeneration.Journal of clinical medicine · 2025Article
- Retinal Vessel Changes in Geographic Atrophy in AMD: Insights From Imaging and Histology.Investigative ophthalmology & visual science · 2025Article
- Retinal neurovascular coupling evaluation with circular-scan OCTA.Optics express · 2025Article
- Nonperfused Retinal Capillaries-A New Method Developed on OCT and OCTA.Investigative ophthalmology & visual science · 2025Article
- The role of the retinal vasculature in age-related macular degeneration: a spotlight on OCTA.Eye (London, England) · 2024Review
- Deep-learning-based automated measurement of outer retinal layer thickness for use in the assessment of age-related macular degeneration, applicable to both swept-source and spectral-domain OCT imaging.Biomedical optics express · 2024Article
- Age-related macular degeneration: suitability of optogenetic therapy for geographic atrophy.Frontiers in neuroscience · 2024Review
- Utility of En Face OCT for the Detection of Clinically Unsuspected Retinal Neovascularization in Patients with Diabetic Retinopathy.Ophthalmology. Retina · 2023Observational
- Signal attenuation-compensated projection-resolved OCT angiography.Biomedical optics express · 2023Article
- Deep-Learning-Aided Diagnosis of Diabetic Retinopathy, Age-Related Macular Degeneration, and Glaucoma Based on Structural and Angiographic OCT.Ophthalmology science · 2023Article
- Clinicopathologic Findings in Three Siblings With Geographic Atrophy.Investigative ophthalmology & visual science · 2023Article
- Atrophy of retinal vessels in neovascular age-related macular degeneration following long-term treatment with 20 intravitreal anti-VEGF injections.BMC ophthalmology · 2022Article
- Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults.Eye and vision (London, England) · 2022Article
- Research Advances in Age-Related Macular Degeneration.Journal of clinical medicine · 2022Article
- Retinal Vessel Density in Age-Related Macular Degeneration Patients with Geographic Atrophy.Journal of clinical medicine · 2022Article
- Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography.Investigative ophthalmology & visual science · 2021Article
- Topographic Variation of Retinal Vascular Density in Normal Eyes Using Optical Coherence Tomography Angiography.Translational vision science & technology · 2021Article
- An end-to-end network for segmenting the vasculature of three retinal capillary plexuses from OCT angiographic volumes.Biomedical optics express · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo compare retinal vessel density in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to age-matched healthy eyes by using projection-resolved optical coherence tomography angiography (PR-OCTA).
designProspective cross-sectional study.
methodsStudy participants underwent macular 3- × 3-mm OCTA scans with spectral domain OCTA. Reflectance-compensated retinal vessel densities were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Quantitative analysis using normalized deviation compared the retinal vessel density in GA regions, 500-μm GA rim regions, and non-GA regions to similar macular locations in control eyes.
resultsTen eyes with GA and 10 control eyes were studied. Eyes with GA had significantly lower vessel density in the SVC (54.8 ± 2.4% vs. 60.8 ± 3.1%; P < 0.001), ICP (34.0 ± 1.5% vs. 37.3 ± 1.7%; P = 0.003) and DCP (24.4 ± 2.3% vs. 28.0 ± 2.3%; P < 0.001) than control eyes. Retinal vessel density within the GA region decreased significantly in SVC, ICP, and DCP. Retinal vessel density in the GA rim region decreased in SVC and ICP but not in DCP. The non-GA region did not significantly deviate from normal controls. Eyes with GA had significantly reduced photoreceptor layer thickness; but similar nerve fiber layer, ganglion cell complex, inner nuclear layer, and outer plexiform layer thickness.
conclusionsEyes with GA have reduced retinal vessel density in SVC, ICP, and DCP compared to those in controls. Loss is greatest within regions of GA. Vessel density may be more sensitive than retinal layer thickness measurement in the detection of inner retinal change in eyes with GA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.