Evidence map›Paper›PMID 31526762›Full record

ArticleCancer cell2019

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.

Brian Krug, Nicolas De Jay, Ashot S Harutyunyan, Shriya Deshmukh, Dylan M Marchione, Paul Guilhamon, Kelsey C Bertrand, Leonie G Mikael, Melissa K McConechy, Carol C L Chen and 18 more

Abstract readPublished Erratum
In one paragraph

Article in Cancer cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Diffuse midline gliomas, H3K27M-altered, of the pineal gland: the first synaptophysin-positive case and a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  8. Acetylation of Histone H3 in Cancer Progression and Prognosis.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Polycomb Repressive Complex 2 in Oncology.Cancer treatment and research · 2023
    Article
  15. Article
  16. Article
  17. The Effect ofCancers · 2022
    Article
  18. Review
  19. Article
  20. Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Brian Krug
Nicolas De Jay
Ashot S Harutyunyan
Shriya Deshmukh
Dylan M Marchione
Paul Guilhamon
Kelsey C Bertrand
Leonie G Mikael
Melissa K McConechy
Carol C L Chen
Sima Khazaei
Robert F Koncar
Sameer Agnihotri
Damien Faury
Benjamin Ellezam
Alexander G Weil
Josie Ursini-Siegel
Daniel D De Carvalho
Peter B Dirks
Peter W Lewis
Paolo Salomoni
Mathieu Lupien
Cheryl Arrowsmith
Paul F Lasko
Benjamin A Garcia
Claudia L Kleinman
Nada Jabado
Stephen C Mack

Funding

Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6M
Medical Research Council MR/M00094X/1NCI NIH HHS P01 CA196539
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID31526762
PMCPMC6949014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.