ArticlePediatric neurology2019
Quality of Life in Children With Sturge-Weber Syndrome.
Article in Pediatric neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Epilepsy, Cognitive, and Behavioral Outcomes in Neurocutaneous Syndromes: A Comparative Review of NF1, TSC, and Sturge-Weber Syndrome.Children (Basel, Switzerland) · 2026Review
- New Onset of Seizures Leading to the Delayed Diagnosis of Sturge-Weber Syndrome in Adulthood: A Case Report.Cureus · 2025Article
- Patient-Reported Outcomes and Psychosocial Impact of Vascular Malformations in Asian Patients.Journal of clinical medicine · 2025Article
- Sturge-Weber syndrome secondary glaucoma: From Pathogenesis to Treatment.Eye and vision (London, England) · 2025Review
- Sturge-Weber Syndrome: A Narrative Review of Clinical Presentation and Updates on Management.Journal of clinical medicine · 2025Review
- A Review of Sturge-Weber Syndrome Brain Involvement, Cannabidiol Treatment and Molecular Pathways.Molecules (Basel, Switzerland) · 2024Review
- Epileptic seizures as an initial symptom for Sturge‑Weber syndrome type III: A report of two cases.Experimental and therapeutic medicine · 2024Article
- Longitudinal prospective study of Sturge-Weber syndrome urine angiogenic factors and neurological outcome.Annals of the Child Neurology Society · 2024Article
- Retrospective Analysis of Presymptomatic Treatment In Sturge-Weber Syndrome.Annals of the Child Neurology Society · 2024Article
- Development of the PROMIS pediatric stigma and extension to the PROMIS pediatric stigma: skin item banks.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Sturge-Weber syndrome: updates in translational neurology.Frontiers in neurology · 2024Review
- Updates on Sturge-Weber Syndrome.Stroke · 2022Review
- Article
- Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome.Pediatric neurology · 2021Article
- Sirolimus Treatment in Sturge-Weber Syndrome.Pediatric neurology · 2021Article
- Sturge-Weber syndrome: an update on the relevant issues for neurosurgeons.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
aimWe assessed the utilization of the National Institutes of Health Quality of Life in Neurological Disorders (Neuro-QoL) in pediatric patients with Sturge-Weber syndrome, a rare neurovascular disorder which frequently results in seizures, brain atrophy, calcification, and a range of neurological impairments.
methodsSubjects were seen clinically and consented for research. All 22 patients filled out the Pediatric Neuro-QoL. The Neuro-QoL subscores were converted to T-scores to compare with the referenced control population. Twenty-one participants also filled out the Brain Vascular Malformation Consortium Database Questionnaire containing data pertaining to Sturge-Weber syndrome-related medical history, medications, comorbidities, and family history. All data were analyzed with a significance threshold of P < 0.05.
resultsCognitive function quality of life was significantly lower (P < 0.001) in pediatric patients with Sturge-Weber syndrome compared with referenced control subjects. Male gender (P = 0.02) was associated with lower cognitive function Neuro-QoL. The extent of skin (R = -0.46, P = 0.04), total eyelid port-wine birthmark (R = -0.56, P = 0.007), eye (R = -0.58, P = 0.005), and total Sturge-Weber syndrome involvement (R = -0.63, P = 0.002) were negatively correlated with cognitive function Neuro-QoL. A younger age at seizure onset was associated with lower cognitive function Neuro-QoL (hazard ratio = 0.90, P = 0.004) even after controlling for extent of brain, skin, or eye involvement. Antidepressant use was associated with lower cognitive function Neuro-QoL (P = 0.005), and cognitive function Neuro-QoL was negatively correlated with depression Neuro-QoL; however, after adjusting for depression this relationship was no longer significant.
conclusionsThe results suggest targeting cognitive function Neuro-QoL in treatment trials and reiterate the prognostic value of early seizure onset. In addition, sex-related differences were noted, which should be further studied.
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