Evidence map›Paper›PMID 31526479›Full record

ArticleeLife2019

Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6.

Yi Xin, Allison Malick, Meiqin Hu, Chengdong Liu, Heya Batah, Haoxing Xu, Cunming Duan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Insulin signaling in development.Development (Cambridge, England) · 2023
    Article
  9. Article
  10. ROS signaling-induced mitochondrial Sgk1 expression regulates epithelial cell renewal.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yi XinDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Allison MalickDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Meiqin HuDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Chengdong LiuDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Heya BatahDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Haoxing XuDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID http://orcid.org/0000-0003-3561-4654
Cunming DuanDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID https://orcid.org/0000-0001-6794-2762
University of Michigan · US

Funding

The Mucolipin TRP Ion ChannelsR01NS062792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2009 to 2018
$3.3M
Ion channels in the tubulovesiclesR01DK115474 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED, DU, WANLU · 2018 to 2022
$1.4M
National Science Foundation IOS-1557850National Science Foundation IOS-1755262NIDDK NIH HHS R01 DK115474NINDS NIH HHS R01 NS062792
6 · The paper itself

Abstract

Epithelial homeostasis and regeneration require a pool of quiescent cells. How the quiescent cells are established and maintained is poorly understood. Here, we report that Trpv6, a cation channel responsible for epithelial Ca

Indexed as

Cell ProliferationAnimalsCalciumCalcium ChannelsEpithelial CellsGene DeletionHumansIntercellular Signaling Peptides and ProteinsSignal TransductionTRPV Cation ChannelsZebrafishZebrafish ProteinsCalciumCalcium ChannelsIntercellular Signaling Peptides and ProteinsTRPV6 protein, humantrpv6 protein, zebrafishTRPV Cation ChannelsZebrafish ProteinsAktCa2+ signalingdevelopmental biologyErkIGF1 receptorPP2ATorzebrafish

Identifiers

PMID31526479
PMCPMC6764821
OpenAlexW2974048575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.