Evidence map›Paper›PMID 31526475›Full record

ArticleeLife2019

A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector.

Charles F Ericson, Fabian Eisenstein, João M Medeiros, Kyle E Malter, Giselle S Cavalcanti, Robert W Zeller, Dianne K Newman, Martin Pilhofer, Nicholas J Shikuma

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
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  8. The spike tip protein of bacteriophage T4.bioRxiv : the preprint server for biology · 2025
    Article
  9. bioRxiv : the preprint server for biology · 2025
    Article
  10. Complete genome sequences of twoMicrobiology resource announcements · 2025
    Article
  11. MyD88 knockdown by RNAi prevents bacterial stimulation of tubeworm metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
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  19. Future research directions of the model marine tubeworm Hydroides elegans and synthesis of developmental staging of the complete life cycle.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Charles F Ericson *Department of Biology, San Diego State University, San Diego, United States.ORCID 0000-0002-2854-0696
Fabian Eisenstein *Department of Biology, Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule, Zürich, Switzerland.
João M MedeirosDepartment of Biology, Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule, Zürich, Switzerland.ORCID 0000-0001-9075-548X
Kyle E MalterDepartment of Biology, San Diego State University, San Diego, United States.ORCID 0000-0002-3056-8751
Giselle S CavalcantiDepartment of Biology, San Diego State University, San Diego, United States.
Robert W ZellerDepartment of Biology, San Diego State University, San Diego, United States.
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-1647-1918
Martin PilhoferDepartment of Biology, Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule, Zürich, Switzerland.
Nicholas J ShikumaDepartment of Biology, San Diego State University, San Diego, United States.ORCID 0000-0001-5518-5020
San Diego State University · USETH Zurich · CHCalifornia Institute of Technology · US

Funding

MicroRNA function in ascidian sensory neuronsR21DC013180 · NIDCD · SAN DIEGO STATE UNIVERSITY · PI ZELLER, ROBERT W · 2014 to 2015
$395k
Pittsburgh-Stellenbosch University AIDS-comorbidities Training Research Program (Pitt-SU AICoTRP)D43TW010340 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NACHEGA, JEAN BISIMWA · 2016 to 2016
$113k
European Research Council 679209NIDCD NIH HHS 1R21DC013180-01A1Office of Naval Research N00014-14-1-0340Office of Naval Research N00014-16-1-2135Office of Naval Research N00014-17-1-2677Swiss National Science Foundation 31003A_179255
6 · The paper itself

Abstract

The swimming larvae of many marine animals identify a location on the sea floor to undergo metamorphosis based on the presence of specific bacteria. Although this microbe-animal interaction is critical for the life cycles of diverse marine animals, what types of biochemical cues from bacteria that induce metamorphosis has been a mystery. Metamorphosis of larvae of the tubeworm

Indexed as

Host Microbial InteractionsMetamorphosis, BiologicalAnimalsBacterial ProteinsCryoelectron MicroscopyElectron Microscope TomographyPolychaetaProtein TransportPseudoalteromonasBacterial Proteinscontractile injection systemdevelopmentinfectious diseasemetamorphosismicrobiologymolecular biophysicsphagestructural biologysymbiosisT6SS

Identifiers

PMID31526475
PMCPMC6748791
OpenAlexW2974869024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.