Evidence map›Paper›PMID 31526452›Full record

ArticleThe Journal of general virology2019

Increased serum sialic acid is associated with morbidity and mortality in a murine model of dengue disease.

Diego A Espinosa, P Robert Beatty, Henry Puerta-Guardo, M Nurul Islam, John T Belisle, Rushika Perera, Eva Harris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Dengue NS1 as a Driver of Immune-Mediated Pathogenesis.Tropical medicine and infectious disease · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diego A EspinosaDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
P Robert BeattyDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
Henry Puerta-GuardoDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.
M Nurul IslamDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
John T BelisleDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Rushika PereraDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA.

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
Dissecting novel mechanisms of dengue virus NS1-induced vascular leakR01AI124493 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS, EVA · 2016 to 2020
$1.9M
Metabolomics-based discovery of small molecule biomarkers for noninvasive dengueR33AI100186 · NIAID · COLORADO STATE UNIVERSITY · PI PERERA, RUSHIKA · 2014 to 2016
$1.3M
NIAID NIH HHS R01 AI124493NIAID NIH HHS R33 AI100186NIAID NIH HHS U19 AI109761
6 · The paper itself

Abstract

Dengue virus (DENV) causes the most prevalent arboviral infection of humans, resulting in a spectrum of outcomes, ranging from asymptomatic infection to dengue fever to severe dengue characterized by vascular leakage and shock. Previously, we determined that DENV nonstructural protein 1 (NS1) induces endothelial hyperpermeability, disrupts the endothelial glycocalyx layer (EGL)

Indexed as

AnimalsBiomarkersChromatography, LiquidDengueDisease Models, AnimalMass SpectrometryMiceN-Acetylneuraminic AcidSerumSurvival AnalysisViral Nonstructural ProteinsBiomarkersN-Acetylneuraminic AcidNS1 protein, Dengue virus type 2Viral Nonstructural Proteinsbiomarkerdengue virusNS1sialic acidvascular leakage

Identifiers

PMID31526452
PMCPMC7011697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.