Evidence map›Paper›PMID 31526329›Full record

ArticleJournal of dental research2019

Estrogen Selectively Enhances TMJ Disc but Not Knee Meniscus Matrix Loss.

Y Park, S Chen, N Ahmad, T Hayami, S Kapila

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. TMD in Females with Menstrual Disorders.International journal of environmental research and public health · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Y ParkDepartment of Human Genetics, School of Medicine, University of Michigan, Ann Arbor, MI, USA.
S ChenDivision of Orthodontics, Department of Orofacial Sciences, University of California, San Francisco, CA, USA.
N AhmadBiology Department, Henry Ford College, Dearborn, MI, USA.
T HayamiDepartment of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, MI, USA.
S KapilaDivision of Orthodontics, Department of Orofacial Sciences, University of California, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of Michigan–Ann Arbor · USWayne County Community College District · US

Funding

Hormone-Receptor-MMP Axis in Degenerative TMJ DiseasesR01DE018455 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAPILA, SUNIL D · 2007 to 2011
$1.8M
NIDCR NIH HHS R01 DE018455
6 · The paper itself

Abstract

The preponderance of temporomandibular joint (TMJ) degenerative disorders in women and their early onset during reproductive years have implicated female sex hormones, particularly 17-β estradiol (E2), in the pathogenesis of these disorders. Nevertheless, the mechanisms by which E2 contributes to TMJ degenerative disorders and the reasons for its targeted effects on the TMJ but not other joints remain poorly understood. Here, we developed an ovariectomized mouse model in which systemic E2 concentrations mimicked those in cycling women, and we determined the effect of E2 on the targeted turnover of TMJ fibrocartilage matrix via E2-induced matrix metalloproteinases MMP9 and MMP13. Infusion of E2 and progesterone (P4; hormone control) over 7 d resulted in 5- and 8-fold greater serum E2 and P4 levels relative to controls, respectively, achieving systemic hormone levels similar to high baseline levels in cycling women. Administration of E2 but not P4 caused a significant loss of TMJ collagen and glycosaminoglycans, which was accompanied by amplification of

Indexed as

AnimalsCartilageEstradiolFemaleKnee JointMatrix Metalloproteinase 13Matrix Metalloproteinase 9MeniscusMiceMice, Inbred C57BLOvariectomyTemporomandibular Joint DiscEstradiolMatrix Metalloproteinase 13Matrix Metalloproteinase 9Mmp13 protein, mouseMmp9 protein, mousecollagenestrogen receptorsextracellular matrixglycosaminoglycansmatrix metalloproteinasestemporomandibular joint disorder

Identifiers

PMID31526329
PMCPMC6873282
OpenAlexW2974686996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.