Evidence map›Paper›PMID 31526218›Full record

Trial reportHuman vaccines & immunotherapeutics2020

A randomized Phase I/II study to evaluate safety and reactogenicity of a heat-stable rotavirus vaccine in healthy adults followed by evaluation of the safety, reactogenicity, and immunogenicity in infants.

Vibhu Kanchan, Khalequ Zaman, Asma Binte Aziz, Sheikh Farzana Zaman, Farzana Zaman, Warda Haque, Mahbuba Khanam, Mohammad Mahbubul Karim, Sachin Kale, Syed Khalid Ali and 7 more

Open access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Vaccines for preventing rotavirus diarrhoea: vaccines in use.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Trial
  3. Trial
  4. Enhancing vaccine stability in transdermal microneedle platforms.Drug delivery and translational research · 2025
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 4 countries.

Vibhu KanchanMSD Wellcome Trust Hilleman Laboratories Pvt. Ltd., New Delhi, India.ORCID 0000-0002-5182-2552
Khalequ Zamanicddr, Dhaka, Bangladesh.
Asma Binte Azizicddr, Dhaka, Bangladesh.
Sheikh Farzana Zamanicddr, Dhaka, Bangladesh.
Farzana Zamanicddr, Dhaka, Bangladesh.
Warda Haqueicddr, Dhaka, Bangladesh.ORCID 0000-0002-5437-6228
Mahbuba Khanamicddr, Dhaka, Bangladesh.
Mohammad Mahbubul Karimicddr, Dhaka, Bangladesh.
Sachin KaleMSD Wellcome Trust Hilleman Laboratories Pvt. Ltd., New Delhi, India.
Syed Khalid AliMSD Wellcome Trust Hilleman Laboratories Pvt. Ltd., New Delhi, India.
Michelle G GoveiaMerck & Co., Inc., Kenilworth, NJ, USA.
Susan S KaplanMerck & Co., Inc., Kenilworth, NJ, USA.
Davinder GillMSD Wellcome Trust Hilleman Laboratories Pvt. Ltd., New Delhi, India.
Wasif Ali Khanicddr, Dhaka, Bangladesh.ORCID 0000-0002-7650-8068
Mohammad Yunusicddr, Dhaka, Bangladesh.
Ajitpal SinghMSD Wellcome Trust Hilleman Laboratories Pvt. Ltd., New Delhi, India.ORCID 0000-0002-1526-6624
John D Clemensicddr, Dhaka, Bangladesh.
International Centre for Diarrhoeal Disease Research · BDHilleman Laboratories (India) · INMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

RotavirusRotavirus InfectionsRotavirus VaccinesAdultAnimalsAntibodies, ViralBangladeshCattleDouble-Blind MethodHot TemperatureHumansImmunogenicity, VaccineInfantVaccines, AttenuatedAntibodies, ViralRotavirus VaccinesVaccines, AttenuatedHeat stable rotavirus vaccineimmunogenicityrandomizedreactogenicitysafety

Identifiers

PMID31526218
PMCPMC7227685
OpenAlexW2974516776

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.