Evidence map›Paper›PMID 31526133›Full record

ArticleToxicologic pathology2019

Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System.

Cynthia L Willard-Mack, Susan A Elmore, William C Hall, Johannes Harleman, C Frieke Kuper, Patricia Losco, Jerold E Rehg, Christine Rühl-Fehlert, Jerrold M Ward, Daniel Weinstock and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Toxicologic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 113 citations in OpenAlex.

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  15. Spontaneous Benign Thymoma in a 10-Week-Old Female ICR (CD-1) Mouse.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  16. First record ofInternational journal for parasitology. Parasites and wildlife · 2025
    Article
  17. Article
  18. Article
  19. Histopathology of spontaneous lesions in FVB/N mice.Journal of toxicologic pathology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 6 countries.

Cynthia L Willard-MackCovance, Somerset, NJ, USA.
Susan A ElmoreThymus subgroup lead.ORCID 0000-0002-1680-9176
William C HallHall Consulting, Inc, Mt Airy, MD, USA.
Johannes HarlemanLymph node subgroup lead.
C Frieke KuperAssociated lymphoid organs subgroup lead.
Patricia LoscoGeneral hematolymphoid subgroup lead.
Jerold E RehgSpleen subgroup leads.
Christine Rühl-FehlertNeoplasm subgroup leads.
Jerrold M WardSpleen subgroup leads.
Daniel WeinstockBone marrow subgroup lead.
Alys BradleyCharles River Laboratories, Tranent, Scotland, United Kingdom.
Satoru HosokawaEisai Co, Ltd, Drug Safety Research Laboratories, Ibaraki, Japan.
Gail PearseGlaxoSmithKline, Ware, United Kingdom.
Beth W MahlerExperimental Pathology Laboratories, Research Triangle Park, NC, USA.
Ronald A HerbertNational Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Charlotte M KeenanCM Keenan ToxPath Consulting, Doylestown, PA, USA.
National Institute of Environmental Health Sciences · USCovance (United States) · USUtrecht University · NLWest Chester University · USBayer (Germany) · DECharles River Laboratories (United Kingdom) · GBExperimental Pathology Laboratories · USJanssen (United States) · USNordic Lymphoma Group · DKSt. Jude Children's Research Hospital · US

Funding

CMPB Pathology Support GroupZICES102505 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HERBERT, RONALD · 2014 to 2021
$67.7M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIC ES102505
6 · The paper itself

Abstract

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative changes in rats and mice. The purpose of this publication is to provide a standardized nomenclature for classifying changes observed in the hematolymphoid organs, including the bone marrow, thymus, spleen, lymph nodes, mucosa-associated lymphoid tissues, and other lymphoid tissues (serosa-associated lymphoid clusters and tertiary lymphoid structures) with color photomicrographs illustrating examples of the lesions. Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. The nomenclature for these organs is divided into 3 terminologies: descriptive, conventional, and enhanced. Three terms are listed for each diagnosis. The rationale for this approach and guidance for its application to toxicologic pathology are described in detail below.

Indexed as

Bone MarrowLymphoid TissueAnimalsAnimals, LaboratoryBiomedical ResearchBone Marrow DiseasesLymphatic DiseasesMiceRatsTerminology as Topicbone marrowdiagnostic criteriaINHANDlymph nodelymphoidMALTnomenclaturespleenthymus

Identifiers

PMID31526133
PMCPMC6752743
OpenAlexW2974850012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.