Evidence map›Paper›PMID 31526052›Full record

ArticleCell transplantation2019

MicroRNA-204-5p Inhibits Ovarian Cancer Cell Proliferation by Down-Regulating USP47.

Liangliang Hu, Helena Kolibaba, Siyou Zhang, Minhua Cao, Huihui Niu, Haoyan Mei, Yaming Hao, Yang Xu, Qinan Yin

Abstract read
In one paragraph

Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. LncRNAIranian journal of public health · 2022
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  16. Role of Ubiquitin-Specific Peptidase 47 in Cancers and Other Diseases.Frontiers in cell and developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liangliang HuMedical faculty of Hubei Polytechnic Institute, Xiaogan, Hubei, China.
Helena KolibabaSt Claraspital Hospital, CH-4058, Basel, Switzerland.
Siyou ZhangDepartment of Obstetrics and Gynecology, China Meitan General Hospital, Beijing, China.
Minhua CaoDepartment of Obstetrics and Gynecology, Suzhou Municipal Hospital, Jiangsu, China.
Huihui NiuDepartment of Obstetrics and Gynecology, Jingmen No.1 People's Hospital, Hubei, China.
Haoyan MeiDepartment of Obstetrics and Gynecology, Jingmen No.1 People's Hospital, Hubei, China.
Yaming HaoWuhan No.5 Hospital, Wuhan, Hubei, China.
Yang XuDepartment of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing, China.
Qinan YinClinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-8560-5751

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is the most lethal gynecologic cancer, and the incidence of OC has risen steadily worldwide. Numerous microRNAs (miRNAs) have been found to be involved in the progression of OC. miR-204-5p is down-regulated and functions as a tumor suppressor in various types of human malignant tumors. However, the biological roles and molecular mechanisms of miR-204-5p in OC still remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in OC tissues. We also observed that miR-204-5p overexpression represses OC cell proliferation. Ubiquitin-specific peptidase 47 (USP47) is verified as the functional target of miR-204-5p, through which it plays an important biological role in OC. Our results uncover new functions and mechanisms for miR-204-5p in the progression of OC, and provide a potential therapeutic target for the treatment of OC.

Indexed as

Cell Line, TumorCell ProliferationDown-RegulationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMicroRNAsOvarian NeoplasmsUbiquitin-Specific ProteasesUbiquitin ThiolesteraseMicroRNAsMIRN204 microRNA, humanUbiquitin-Specific ProteasesUbiquitin ThiolesteraseUSP47 protein, humancell proliferationmiR-204-5povarian cancerUSP47

Identifiers

PMID31526052
PMCPMC7016459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.