ArticleACS chemical biology2019
DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.
Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- DPP9 inhibition boosts antitumor immunity by disrupting BRISC-mediated PD-L1 expression in clear cell renal cell carcinoma.Cell death and differentiation · 2026Article
- An overview of human inflammasomes: Activation and regulation.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Proximity labeling reveals non-catalytic interactions between DPP9 and ubiquitin signaling complexes.Cellular and molecular life sciences : CMLS · 2026Article
- The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex.The Journal of biological chemistry · 2025Article
- The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation.Cell chemical biology · 2024Article
- NLRP inflammasomes in health and disease.Molecular biomedicine · 2024Review
- Association between C10X polymorphism in the CARD8 gene and inflammatory markers in young healthy individuals in the LBA study.BMC cardiovascular disorders · 2024Article
- Small molecule modulators of immune pattern recognition receptors.RSC chemical biology · 2023Review
- Chemical inhibition of DPP9 sensitizes the CARD8 inflammasome in HIV-1-infected cells.Nature chemical biology · 2023Article
- Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.Journal of medicinal chemistry · 2023Article
- Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19.Cell genomics · 2023Article
- Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation.Cell reports · 2023Article
- Causal associations between obstructive sleep apnea and COVID-19: A bidirectional Mendelian randomization study.Sleep medicine · 2023Article
- A shared genetic contribution to osteoarthritis and COVID-19 outcomes: a large-scale genome-wide cross-trait analysis.Frontiers in immunology · 2023Article
- Canonical Inflammasomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.Science immunology · 2022Article
- Viral proteases activate the CARD8 inflammasome in the human cardiovascular system.The Journal of experimental medicine · 2022Article
- Ubiquitination as a key regulatory mechanism for ORedox biology · 2022Article
- DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling.Science immunology · 2022Article
- Activation and Pharmacological Regulation of Inflammasomes.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors of the serine dipeptidyl peptidases DPP8 and DPP9 (DPP8/9) activate both NLRP1 and CARD8. Interestingly, DPP9 binds directly to NLRP1 and CARD8, and this interaction may contribute to the inhibition of NLRP1. Here, we use activity-based probes, reconstituted inflammasome assays, and mass spectrometry-based proteomics to further investigate the DPP9-CARD8 interaction. We show that the DPP9-CARD8 interaction, unlike the DPP9-NLRP1 interaction, is not disrupted by DPP9 inhibitors or CARD8 mutations that block autoproteolysis. Moreover, wild-type, but not catalytically inactive mutant, DPP9 rescues CARD8-mediated cell death in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.