Evidence map›Paper›PMID 31525860›Full record

ArticleJournal of psychiatry & neuroscience : JPN2020

Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression

Tejas Sankar, M. Mallar Chakravarty, Natasha Jawa, Stanley X. Li, Peter Giacobbe, Sidney H. Kennedy, Sakina J. Rizvi, Helen S. Mayberg, Clement Hamani, Andres M. Lozano

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

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  7. Serotonin 5-HTPsychopharmacology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tejas SankarFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
M. Mallar ChakravartyFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Natasha JawaFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Stanley X. LiFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Peter GiacobbeFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Sidney H. KennedyFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Sakina J. RizviFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Helen S. MaybergFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Clement HamaniFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
Andres M. LozanoFrom the Division of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada (Sankar); the Department of Psychiatry, McGill University, Montreal, Quebec, Canada (Chakravarty); the Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada (Chakravarty); the Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (Jawa, Li, Hamani, Lozano); the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada (Giacobbe, Kennedy, Rizvi); and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States (Mayberg).
University of Alberta · CAUniversity of Toronto · CAMcGill University · CA

Funding

CIHR
6 · The paper itself

Abstract

Background: Deep brain stimulation targeting the subcallosal cingulate gyrus (SCG DBS) improves the symptoms of treatment-resistant depression in some patients, but not in others. We hypothesized that there are pre-existing structural brain differences between responders and nonresponders to SCG DBS, detectable using structural MRI. Methods: We studied preoperative, T1-weighted MRI scans of 27 patients treated with SCG DBS from 2003 to 2011. Responders (n = 15) were patients with a >50% improvement in Hamilton Rating Scale for Depression score following 12 months of SCG DBS. Preoperative subcallosal cingulate gyrus grey matter volume was obtained using manual segmentation by a trained observer blinded to patient identity. Volumes of hippocampus, thalamus, amygdala, whole-brain cortical grey matter and white matter volume were obtained using automated techniques. Results: Preoperative subcallosal cingulate gyrus, thalamic and amygdalar volumes were significantly larger in patients who went on to respond to SCG-DBS. Hippocampal volume did not differ between groups. Cortical grey matter volume was significantly smaller in responders, and cortical grey matter:white matter ratio distinguished between responders and nonresponders with high sensitivity and specificity. Limitations: Normalization by intracranial volume nullified some between-group differences in volumetric measures. Conclusion: There are structural brain differences between patients with treatment-resistant depression who respond to SCG DBS and those who do not. Specifically, the structural integrity of the subcallosal cingulate gyrus target region and its connected subcortical areas, and variations in cortical volume across the entire brain, appear to be important determinants of response. Structural MRI shows promise as a biomarker in deep brain stimulation for depression, and may play a role in refining patient selection for future trials.

Indexed as

Deep Brain StimulationOutcome Assessment, Health CareAdultAmygdalaBiomarkersDepressive Disorder, Treatment-ResistantFemaleGray MatterGyrus CinguliHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesThalamusBiomarkers

Identifiers

PMID31525860
PMCPMC6919920
OpenAlexW2996585831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.