Evidence map›Paper›PMID 31525778›Full record

ArticleEuropean journal of dentistry2019

Osteogenic Differentiation and Biocompatibility of Bovine Teeth Scaffold with Rat Adipose-derived Mesenchymal Stem Cells.

Desi Sandra Sari, Ernie Maduratna, Ferdiansyah, Fourier Dzar Eljabbar Latief, Satuman, Alexander Patera Nugraha, Ketut Sudiana, Fedik Abdul Rantam

Abstract read
In one paragraph

Article in European journal of dentistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Role of Adipose-Derived Mesenchymal Stem Cells in Bone Regeneration.International journal of molecular sciences · 2024
    Review
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  18. Application of Adipose Tissue Stem Cells in Regenerative Dentistry: A Systematic Review.Journal of International Society of Preventive & Community Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Desi Sandra SariFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ernie MaduratnaDepartment of Periodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ferdiansyah
Fourier Dzar Eljabbar LatiefMicro-CT Laboratory, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, Indonesia.
Satuman
Alexander Patera NugrahaFaculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Ketut SudianaDepartment of Microscope Electron, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Fedik Abdul RantamStem Cells Research and Development Center, Universitas Airlangga, Surabaya, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdipose-derived mesenchymal stem cells (ADMSCs) have great potential for regenerative medicine. These have been combined with biomaterials such as Bovine teeth that are preferred as a periodontal regeneration material. The main purpose of this study is to evaluate and analyze a biocompatibility test and osteogenic differentiation of bovine teeth scaffold seeded with ADMSCs in vitro. MATERIALS AND

methodsA true experimental study with post-test only group design was conducted. Random sampling and Lameshow's formula were used to determine the sample. The scaffold, obtained from bovine teeth as the bone graft material, was analyzed using 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and its attachment was evaluated by scanning electron microcopy (SEM) and micro-computed tomography with ADMSCs. ADMDSCs attachment present in the bovine teeth scaffold was assessed using SEM at 1-hour, 12-hour, and 24-hour intervals. STATISTICAL ANALYSIS: Analysis of variance was used to analyze the MTT assay results (

resultsThe highest viability of cells (97.08%) was found at a concentration of 10% by means of an MTT test (

conclusionThe scaffold from bovine teeth is biocompatible and accelerates osteogenic differentiation of ADMSC.

Identifiers

PMID31525778
PMCPMC6777160

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.