ArticleNeuroImage2019
7T quantitative magnetization transfer (qMT) of cortical gray matter in multiple sclerosis correlates with cognitive impairment.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed.
- ISMRM Clinical Focus Meeting 2023: "Imaging the Fire in the Brain".Journal of magnetic resonance imaging : JMRI · 2025Article
- Comparison and calibration of MP2RAGE quantitative T1 values to multi-TI inversion recovery T1 values.Magnetic resonance imaging · 2025Article
- Spin-lock based fast whole-brain 3D macromolecular proton fraction mapping of relapsing-remitting multiple sclerosis.Scientific reports · 2024Article
- An in vivo implementation of the MEX MRI for myelin fraction of mice brain.Magma (New York, N.Y.) · 2022Article
- Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis.Brain communications · 2022Review
- Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications.Frontiers in neuroscience · 2022Review
- Relaxation-Compensated Chemical Exchange Saturation Transfer MRI in the Brain at 7T: Application in Relapsing-Remitting Multiple Sclerosis.Frontiers in neurology · 2022Article
- Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis.Brain sciences · 2021Review
- In vivo tensor-valued diffusion MRI of focal demyelination in white and deep grey matter of rodents.NeuroImage. Clinical · 2021Article
- Rapid whole-brain quantitative magnetization transfer imaging using 3D selective inversion recovery sequences.Magnetic resonance imaging · 2020Article
- Recent advances in understanding multiple sclerosis.F1000Research · 2019Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Cognitive impairment (CI) is a major manifestation of multiple sclerosis (MS) and is responsible for extensively hindering patient quality of life. Cortical gray matter (cGM) damage is a significant contributor to CI, but is poorly characterized by conventional MRI let alone with quantitative MRI, such as quantitative magnetization transfer (qMT). Here we employed high-resolution qMT at 7T via the selective inversion recovery (SIR) method, which provides tissue-specific indices of tissue macromolecular content, such as the pool size ratio (PSR) and the rate of MT exchange (kmf). These indices could represent expected demyelination that occurs in the presence of gray matter damage. We utilized selective inversion recovery (SIR) qMT which provides a low SAR estimate of macromolecular-bulk water interactions using a tailored, B1 and B0 robust inversion recovery (IR) sequence acquired at multiple inversion times (TI) at 7T and fit to a two-pool model of magnetization exchange. Using this sequence, we evaluated qMT indices across relapsing-remitting multiple sclerosis patients (N = 19) and healthy volunteers (N = 37) and derived related associations with neuropsychological measures of cognitive impairment. We found a significant reduction in k
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.