ArticlePloS one2019
Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 92 citations in OpenAlex.
- Effect of Rosemary Cream on Episiotomy Wound Healing in Primiparous Women: A Randomized Clinical Trial.BMC complementary medicine and therapies · 2022Trial
- Wound Healing Activity of Iron Oxide Nanoparticles; Comparative In Vivo Study onAntibiotics (Basel, Switzerland) · 2026Article
- Progresses in Wound Healing: Integrating Nutrition, Physical Therapy, Traditional and Alternative Medicine, and Novel Technologies.Current diabetes reviews · 2026Review
- The nephroprotective potential of russelioside B isolated from Caralluma quadrangula in gentamicin-induced acute kidney injury via modulation of SIRT-1 pathway.Scientific reports · 2025Article
- Wound Healing Traits ofArchives of Razi Institute · 2025Article
- Essential oils: a potential alternative with promising active ingredients for pharmaceutical formulations in chronic wound management.Inflammopharmacology · 2024Review
- Antioxidant Potential of Medicinal Plants in the Treatment of Scabies Infestation.Molecules (Basel, Switzerland) · 2024Review
- Polymer-Based Wound Dressings Loaded with Essential Oil for the Treatment of Wounds: A Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The applications and mechanisms ofFrontiers in pharmacology · 2024Review
- Enhancing Wound Healing: A Novel Topical Emulsion Combining CW49 Peptide and Lavender Essential Oil for Accelerated Regeneration and Antibacterial Protection.Pharmaceutics · 2023Article
- Synergistic Effect ofMolecules (Basel, Switzerland) · 2023Article
- Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review.Antioxidants (Basel, Switzerland) · 2023Review
- Review
- Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Essential Oils in the Treatment of Various Types of Acne-A Review.Plants (Basel, Switzerland) · 2022Review
- Comparative Metabolic Study ofPlants (Basel, Switzerland) · 2022Article
- Thioctamer: a novel thioctic acid-glatiramer acetate nanoconjugate expedites wound healing in diabetic rats.Drug delivery · 2022Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Evaluation of the Cardiac Electrophysiological and Haemodynamic Effects ofPharmaceuticals (Basel, Switzerland) · 2022Article
- Novel Nanoconjugate of Apamin and Ceftriaxone for Management of Diabetic Wounds.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigates the wound healing potential of three chitosan-based topical preparations loaded with either tea tree essential oil, rosemary essential oil or a mixture of both oils in vivo. Essential oils of M. alternifolia and R. officinalis were analyzed using GC/MS. Essential oil-loaded chitosan topical preparations were formulated. Wound healing potential was evaluated in vivo using an excision wound model in rats. GC/MS analysis of M. alternifolia and R. officinalis essential oils revealed richness in oxygenated monoterpenes, representing 51.06% and 69.61% of the total oil composition, respectively. Topical application of chitosan-based formulation loaded with a mixture of tea tree and rosemary oils resulted in a significant increase in wound contraction percentage compared to either group treated with individual essential oils and the untreated group. Histopathological examination revealed that topical application of tea tree and rosemary oil combination demonstrated complete re-epithelialization associated with activated hair follicles. The high percentage of oxygenated monoterpenes in both essential oils play an important role in the antioxidant and wound healing potential observed herein. Incorporation of tea tree and rosemary essential oils in chitosan-based preparations in appropriate combination could efficiently promote different stages of wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.