Evidence map›Paper›PMID 31525165›Full record

ReviewExercise and sport sciences reviews2019

Macrophage Regulation of Muscle Regrowth From Disuse in Aging.

Paul T Reidy, Esther E Dupont-Versteegden, Micah J Drummond

Open access · greenAbstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Neuromuscular electrical stimulation and protein during bed rest increases CD11bApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Paul T ReidyDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT.
Esther E Dupont-VersteegdenDepartment of Rehabilitation Sciences, University of Kentucky, Lexington, KY.
Micah J DrummondDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT.
University of Utah · USUniversity of Kentucky · US

Funding

Mechanisms underlying anabolic effects of cyclic compressive loading in muscleR01AT009268 · NCCIH · UNIVERSITY OF KENTUCKY · PI BUTTERFIELD, TIMOTHY ALAN, DUPONT-VERSTEEGDEN, ESTHER E · 2017 to 2021
$2.3M
Novel molecular mechanisms of skeletal muscle insulin resistance in physically inactive older adultsR01AG050781 · NIA · UNIVERSITY OF UTAH · PI DRUMMOND, MICAH J · 2016 to 2020
$1.7M
Cyclic compressive loading to negate atrophy and impaired regrowth in aged muscleR21AG042699 · NIA · UNIVERSITY OF KENTUCKY · PI BUTTERFIELD, TIMOTHY ALAN, DUPONT-VERSTEEGDEN, ESTHER E · 2013 to 2014
$412k
Macrophages to Enhance Recovery of Skeletal Muscle following Disuse Atrophy in AgingF32AR072481 · NIAMS · UNIVERSITY OF UTAH · PI REIDY, PAUL TIMOTHY · 2017 to 2018
$115k
NCCIH NIH HHS R01 AT009268NIAMS NIH HHS F32 AR072481NIA NIH HHS R01 AG050781NIA NIH HHS R21 AG042699
6 · The paper itself

Abstract

Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults.

Indexed as

AgingAnimalsExercise TherapyHumansImmunotherapyMacrophagesModels, AnimalMuscle, SkeletalMuscular Atrophy

Identifiers

PMID31525165
PMCPMC9236178
OpenAlexW2954849674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.