Evidence map›Paper›PMID 31525142›Full record

ReviewAnnual review of vision science2019

Imaging Retinal Activity in the Living Eye.

Jennifer J Hunter, William H Merigan, Jesse B Schallek

Abstract readReview
In one paragraph

Review in Annual review of vision science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Frontiers in ophthalmology · 2025
    Review
  3. Article
  4. Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Schizophrenia in Translation: Why the Eye?Schizophrenia bulletin · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Oxidative Stress and the Role of NADPH Oxidase in Glaucoma.Antioxidants (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Adaptive optics for high-resolution imaging.Nature reviews. Methods primers · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer J HunterFlaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York 14604, USA; email: jhunter@ur.rochester.edu, wmerigan@ur.rochester.edu, jschall3@ur.rochester.edu.
William H MeriganFlaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York 14604, USA; email: jhunter@ur.rochester.edu, wmerigan@ur.rochester.edu, jschall3@ur.rochester.edu.
Jesse B SchallekFlaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, New York 14604, USA; email: jhunter@ur.rochester.edu, wmerigan@ur.rochester.edu, jschall3@ur.rochester.edu.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI Susana Marcos · 1985 to 2026
$17.5M
Physiological and perceptual examination of vision restoration R01EY021166 · NEI · UNIVERSITY OF ROCHESTER · PI MERIGAN, WILLIAM H · 2011 to 2023
$8.4M
RETINAL MECHANISMS AND VISUAL RESOLUTIONR01EY004367 · NEI · UNIVERSITY OF ROCHESTER · PI HUNTER, JENNIFER J, WILLIAMS, DAVID R · 1986 to 2020
$7.3M
Non-invasive, living histology of capillary structure and single cell blood flow in mouse model of diabetic retinopathyR01EY028293 · NEI · UNIVERSITY OF ROCHESTER · PI SCHALLEK, JESSE BARRETT · 2017 to 2025
$4.2M
High-Resolution Functional Imaging of the RetinaR01EY022371 · NEI · UNIVERSITY OF WATERLOO · PI Jennifer J Hunter · 2012 to 2026
$4.1M
Accelerating vision restoration with in-vivo cellular imaging of retinal functionU01EY025497 · NEI · UNIVERSITY OF ROCHESTER · PI WILLIAMS, DAVID R · 2015 to 2019
$4.1M
Non-invasive assessment of retinal functionR01EB002843 · NIBIB · UPSTATE MEDICAL UNIVERSITY · PI TS'O, DANIEL Y · 2003 to 2007
$1.7M
NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY004367NEI NIH HHS R01 EY021166NEI NIH HHS R01 EY022371NEI NIH HHS R01 EY028293NEI NIH HHS U01 EY025497NIBIB NIH HHS R01 EB002843
6 · The paper itself

Abstract

Retinal function has long been studied with psychophysical methods in humans, whereas detailed functional studies of vision have been conducted mostly in animals owing to the invasive nature of physiological approaches. There are exceptions to this generalization, for example, the electroretinogram. This review examines exciting recent advances using in vivo retinal imaging to understand the function of retinal neurons. In some cases, the methods have existed for years and are still being optimized. In others, new methods such as optophysiology are revealing novel patterns of retinal function in animal models that have the potential to change our understanding of the functional capacity of the retina. Together, the advances in retinal imaging mark an important milestone that shifts attention away from anatomy alone and begins to probe the function of healthy and diseased eyes.

Indexed as

AnimalsHumansOphthalmoscopyOptics and PhotonicsRetinaRetinal NeuronsTomography, Optical CoherenceVision, Ocularadaptive opticscalcium indicatorfunctional imagingintrinsic signalsneurovascular couplingoptical coherence tomography

Identifiers

PMID31525142
PMCPMC7001891

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.