Evidence map›Paper›PMID 31525068›Full record

ReviewCirculation. Heart failure2019

Heart Rate and Heart Failure With Preserved Ejection Fraction: Time to Slow β-Blocker Use?

Markus Meyer, Martin M LeWinter

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Circulation. Heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05745337 phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Improving Outcomes in Atrial Fibrillation Patients Aided by Implantable Cardiac Monitor: Evaluation of Chronic Beta-blocker Use Versus As-needed Pharmacological Rate Control

TypeinterventionalSponsorUniversity of VermontRan2023 to 2025Enrolled20ConditionsAtrial Fibrillation, Diastolic Dysfunction, HFpEF - Heart Failure With Preserved Ejection FractionArmsAs needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil)
NCT07589452 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Allometric Pacing Rate on Ventricular Diastolic Function and Cerebral Blood Flow in Hypertensive Patients With Sinus Node Dysfunction

TypeinterventionalSponsorMedtronic Cardiac Rhythm and Heart FailureRan2026 to 2028Enrolled70ConditionsBradycardiaArmsPersonalized lower rate pacing, Standard lower rate pacing
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Peak OESC heart failure · 2022
    Trial
  5. Trial
  6. Hypertension: a missing piece in HFpEF?Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Personalized accelerated physiologic pacing.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  19. Hypertensive Heart Failure.Journal of clinical medicine · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Markus MeyerCardiology Unit, Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington.
Martin M LeWinterCardiology Unit, Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington.

Funding

Myofilament-based mechanisms of diastolic dysfunction in HFpEFR01HL118524 · NHLBI · UNIVERSITY OF ARIZONA · PI GRANZIER, HENK L., LEWINTER, MARTIN M · 2014 to 2017
$2.5M
Sarcolemmal Calcium Extrusion Defect in Patients with Diastolic DysfunctionR01HL122744 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LUSTGARTEN, DANIEL L, MEYER, MARKUS · 2015 to 2019
$1.9M
NHLBI NIH HHS R01 HL118524NHLBI NIH HHS R01 HL122744
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adrenergic beta-AntagonistsHeart FailureHeart RateHumansStroke VolumeAdrenergic beta-Antagonistsatrial fibrillationbeta blockersheart failureheart ratehypertension

Identifiers

PMID31525068
PMCPMC6750011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.