ArticleJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases2021
The Relationship Between Autonomic Dysfunction of the Gastrointestinal Tract and Emotional Distress in Patients With Systemic Sclerosis.
Article in Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Transcutaneous auricular branch vagal nerve stimulation as a non-invasive add-on therapeutic approach for pain in systemic sclerosis.RMD open · 2023Trial
- Proteome-wide serology reveals immune-defined subtypes of gastrointestinal disease in systemic sclerosis.bioRxiv : the preprint server for biology · 2026Article
- Eradication of Small Intestinal Bacterial Overgrowth in Systemic Sclerosis: Current Treatment and Perspectives-A Narrative Review.Biomedicines · 2025Review
- Frequency of dysphagia among patients submitted to a rheumatology department: a cross-sectional analysis based on the EAT-10 questionnaire.Rheumatology international · 2025Article
- Impact of gastrointestinal symptoms and psychological distress on quality of life in systemic sclerosis: a cross-sectional study.BMJ open · 2024Article
- Severity and impact of digestive impairment perceived by patients with systemic sclerosis: a cross-sectional study.BMJ open · 2024Article
- Diffuse Gastrointestinal Motor Compromise in Patients with Scleroderma: Utility of Minimally Invasive Techniques.Digestive diseases and sciences · 2024Article
- A complex interplay between autonomic symptoms and symptoms of depression, anxiety, and stress.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Sympatho-Vagal Dysfunction in Systemic Sclerosis: A Follow-Up Study.Life (Basel, Switzerland) · 2022Article
- The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases.International journal of molecular sciences · 2022Review
- Gastrointestinal manifestations of systemic sclerosis: An updated review.World journal of clinical cases · 2021Review
- Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis.International journal of environmental research and public health · 2021Article
- Gastrointestinal involvement in systemic sclerosis: an update.Current opinion in rheumatology · 2019Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesWe hypothesized that emotional distress in systemic sclerosis (SSc) patients with moderate to severe gastrointestinal (GI) dysfunction is associated with dysautonomia. We sought to determine (1) the clinical characteristics associated with emotional distress in SSc, (2) the odds of having dysautonomia in those with emotional distress, and (3) whether GI dysautonomia, as measured by the Survey of Autonomic Symptoms (SAS), correlates with GI dysautonomia on the Composite Autonomic Symptom Score-31 (COMPASS-31).
methodsClinical and demographic features from our prospective cohort study were compared among SSc patients with and without GI-associated emotional distress (University of California at Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 well-being subscale >0.5 or ≤0.5) in cross-sectional analysis. Covariates/confounders independently associated with emotional distress were used to construct multivariable logistic regression models. The COMPASS-31 and SAS GI subdomains were compared with Spearman correlation.
resultsForty-six patients with SSc were enrolled in the study. In univariate analyses, age (odds ratio [OR], 1.06; p = 0.026), severity of GI dysautonomia (COMPASS-31: OR, 1.41; p = 0.003), anti-centromere (A/B) antibodies (OR, 3.60; p = 0.044), and anti-PM-Scl (75/100) antibodies (OR, 0.15; p = 0.035) were associated with emotional distress. In the adjusted model, those with more severe GI dysautonomia remained more likely to have emotional distress (OR, 1.85; p = 0.026); those with anti-PM-Scl (75/100) antibodies were less likely to have emotional distress (OR, 0.03; p = 0.031). The SAS and COMPASS-31 GI subdomains moderately correlated (ρ = 0.68, p < 0.001).
conclusionsIn SSc, increased symptom burden related to GI dysautonomia is associated with emotional distress. Multidisciplinary approaches addressing both the physical and emotional needs of the SSc patient may be warranted to optimize patient care.
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