Evidence map›Paper›PMID 31524827›Full record

SynthesisMedicine and science in sports and exercise2020

Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.

Jonna K VAN Vulpen, Maike G Sweegers, Petra H M Peeters, Kerry S Courneya, Robert U Newton, Neil K Aaronson, Paul B Jacobsen, Daniel A Galvão, Mai J Chinapaw, Karen Steindorf and 35 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine and science in sports and exercise, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  13. Association of self-directed walking with toxicity moderation during chemotherapy for the treatment of early breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  14. Perceived facilitators and barriers by esophageal cancer survivors participating in a post-treatment exercise program.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Jonna K VAN VulpenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, THE NETHERLANDS.
Maike G Sweegers
Petra H M PeetersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, THE NETHERLANDS.
Kerry S CourneyaFaculty of Kinesiology, Sport and Recreation, University of Alberta, Edmonton, Alberta, CANADA.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Neil K AaronsonDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, THE NETHERLANDS.
Paul B JacobsenDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Mai J ChinapawAmsterdam UMC, Vrije Universiteit, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, THE NETHERLANDS.
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, GERMANY.
Melinda L IrwinYale School of Public Health, New Haven, CT.
Martijn M StuiverCenter for Quality of Life, Netherlands Cancer Institute, Amsterdam, THE NETHERLANDS.
Sandi HayesSchool of Public Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, AUSTRALIA.
Kathleen A GriffithThe George Washington University School of Nursing, Washington, DC.
Ilse MestersDepartment of Epidemiology, Maastricht University, THE NETHERLANDS.
Hans KnoopAmsterdam UMC, University of Amsterdam, Department of Medical Psychology, Amsterdam, THE NETHERLANDS.
Martine M Goedendorp
Nanette MutriePhysical Activity for Health Research Center, University of Edinburgh, Edinburgh, UNITED KINGDOM.
Amanda J DaleySchool of Sport, Exercise and Health Sciences, University of Loughborough, Loughborough, Leicestershire, UNITED KINGDOM.
Alex McConnachieInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UNITED KINGDOM.
Martin Bohus
Lene Thorsen
Karl-Heinz SchulzAthleticum-Competence Center for Sports- and Exercise Medicine and Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY.
Camille E ShortFreemasons Foundation Centre of Men's Health, School of Medicine, University of Adelaide, SA, AUSTRALIA.
Erica L JamesSchool of Medicine & Public Health, the University of Newcastle, Callaghan, NSW, AUSTRALIA.
Ronald C PlotnikoffPriority Research Centre for Physical Activity and Nutrition, the University of Newcastle, Callaghan, NSW, AUSTRALIA.
Martina E SchmidtDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, GERMANY.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT.
Marc VAN BeurdenNetherlands Cancer Institute, Amsterdam, THE NETHERLANDS.
Hester S OldenburgNetherlands Cancer Institute, Amsterdam, THE NETHERLANDS.
Gabe S SonkeNetherlands Cancer Institute, Amsterdam, THE NETHERLANDS.
Wim H VAN Harten
Kathryn H SchmitzDepartment of Public Health Science, College of Medicine and Cancer Institute, Pennsylvania State University, Hershey, PA.
Kerri M Winters-StoneKnight Cancer Institute, School of Nursing, Oregon Health & Science University, Portland, OR.
Miranda J VelthuisNetherlands comprehensive cancer organisation (IKNL), Utrecht, THE NETHERLANDS.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Willem VAN MechelenAmsterdam UMC, Vrije Universiteit, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, THE NETHERLANDS.
Marie José KerstenAmsterdam UMC, University of Amsterdam, Department of Hematology, Amsterdam, THE NETHERLANDS.
Frans NolletAmsterdam UMC, University of Amsterdam Department of Rehabilitation, Amsterdam Movement Sciences, Amsterdam, THE NETHERLANDS.
Jennifer WenzelJohns Hopkins School of Nursing, Johns Hopkins School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD.
Joachim Wiskemann
Irma M Verdonck-DE Leeuw
Johannes Brug
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, THE NETHERLANDS.
Laurien M Buffart

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Intramural NIH HHS Z99 CA999999NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

purposeFatigue is a common and potentially disabling symptom in patients with cancer. It can often be effectively reduced by exercise. Yet, effects of exercise interventions might differ across subgroups. We conducted a meta-analysis using individual patient data of randomized controlled trials (RCT) to investigate moderators of exercise intervention effects on cancer-related fatigue.

methodsWe used individual patient data from 31 exercise RCT worldwide, representing 4366 patients, of whom 3846 had complete fatigue data. We performed a one-step individual patient data meta-analysis, using linear mixed-effect models to analyze the effects of exercise interventions on fatigue (z score) and to identify demographic, clinical, intervention- and exercise-related moderators. Models were adjusted for baseline fatigue and included a random intercept on study level to account for clustering of patients within studies. We identified potential moderators by testing their interaction with group allocation, using a likelihood ratio test.

resultsExercise interventions had statistically significant beneficial effects on fatigue (β = -0.17; 95% confidence interval [CI], -0.22 to -0.12). There was no evidence of moderation by demographic or clinical characteristics. Supervised exercise interventions had significantly larger effects on fatigue than unsupervised exercise interventions (βdifference = -0.18; 95% CI -0.28 to -0.08). Supervised interventions with a duration ≤12 wk showed larger effects on fatigue (β = -0.29; 95% CI, -0.39 to -0.20) than supervised interventions with a longer duration.

conclusionsIn this individual patient data meta-analysis, we found statistically significant beneficial effects of exercise interventions on fatigue, irrespective of demographic and clinical characteristics. These findings support a role for exercise, preferably supervised exercise interventions, in clinical practice. Reasons for differential effects in duration require further exploration.

Indexed as

Exercise TherapyFatigueHumansNeoplasmsQuality of LifeRandomized Controlled Trials as Topic

Identifiers

PMID31524827
PMCPMC6962544

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.